Links among glaucoma, neurodegenerative, and vascular diseases of the central nervous system

被引：62

作者：

Nucci, Carlo ^{[1
]}

Martucci, Alessio ^{[1
]}

Cesareo, Massimo ^{[1
]}

Garaci, Francesco ^{[2
]}

Morrone, Luigi Antonio ^{[3
,4
]}

Russo, Rossella ^{[3
]}

Corasaniti, Maria Tiziana ^{[5
]}

Bagetta, Giacinto ^{[3
,4
]}

Mancino, Raffaele ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Surg, Ophthalmol Unit, Rome, Italy

[2] Univ Roma Tor Vergata, Tor Vergata Univ Hosp, Dept Biomed & Prevent, Diagnost Imaging Sect, Rome, Italy

[3] Univ Calabria, Dept Pharm & Hlth & Nutr Sci, Sect Preclin & Translat Pharmacol, Arcavacata Di Rende, Italy

[4] Univ Calabria, Univ Consortium Adapt Disorders & Head Pain UCHAD, Sect Neuropharmacol Normal & Pathol Neuronal Plas, Arcavacata Di Rende, Italy

[5] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

来源：

NEW TRENDS IN BASIC AND CLINICAL RESEARCH OF GLAUCOMA: A NEURODEGENERATIVE DISEASE OF THE VISUAL SYSTEM, PT B | 2015年 / 221卷

关键词：

Glaucoma; Alzheimer; Parkinson; Leber; Cerebrovascular diseases; OPEN-ANGLE GLAUCOMA; NORMAL-TENSION GLAUCOMA; HEREDITARY OPTIC NEUROPATHY; LATERAL GENICULATE-NUCLEUS; CEREBROSPINAL-FLUID PRESSURE; AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MITOCHONDRIAL DYSFUNCTION; NEURAL DEGENERATION;

D O I：

10.1016/bs.pbr.2015.04.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glaucoma is the leading cause of irreversible blindness worldwide. Although the intraocular pressure (IOP) has been considered for long time the key point and the only treatable risk factor of the disease, there are cases in which glaucoma continues to progress despite normal IOP values. Vision loss in glaucoma is related to a selective decrease in the number of retinal ganglion cells by apoptosis that is associated to alterations of the central visual pathways. Interestingly, similar events have been also described in disorders of the central nervous system (CNS), such as Alzheimer's disease, Parkinson's disease, Leber's hereditary optic neuropathy, and cerebrovascular diseases. In this review, we discuss recent evidence supporting pathological links between glaucoma and disorders of the CNS.

引用

页码：49 / 65

页数：17

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