Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected γδ T-cell-deficient mice

被引：6

作者：

Bockenstedt, LK

Shanafelt, MC

Belperron, A

Mao, JL

Barthold, SW

机构：

[1] Yale Univ, Sch Med, Rheumatol Sect, Dept Internal Med, New Haven, CT 06520 USA

[2] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 05期

关键词：

D O I：

10.1128/IAI.71.5.2938-2940.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In murine Lyme borreliosis, the absence of gammadelta T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gammadelta T cells are present, suggesting that vector effects can negate gammadelta T-cell functions in vivo.

引用

收藏

页码：2938 / 2940

页数：3

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