Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarin-derived ligand 3-(1-(3-hydroxypropylamino) ethylidene) chroman-2,4-dione. Crystal structure of the 3-(1-(3-hydroxypropylamino) ethylidene)-chroman-2,4-dione

被引：27

作者：

Avdovic, Edina H. ^{[1
,4
]}

Stojkovic, Danijela L. J. ^{[1
]}

Jevtic, Verica V. ^{[1
]}

Kosic, Milica ^{[2
]}

Ristic, Biljana ^{[2
]}

Harhaji-Trajkovic, Ljubica ^{[3
]}

Vukic, Milena ^{[1
]}

Vukovic, Nenad ^{[1
]}

Markovic, Zoran S. ^{[4
]}

Potocnak, Ivan ^{[5
]}

Trifunovic, Srecko R. ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanov 12, Kragujevac 34000, Serbia

[2] Univ Belgrade, Inst Microbiol & Immunol, Sch Med, Dr Subot 1, Belgrade 11000, Serbia

[3] Univ Belgrade, Inst Biol Res, Despota Stefana Blvd 142, Belgrade 11000, Serbia

[4] State Univ Novi Pazar, Dept Chem Technol Sci, Novi Pazar 36300, Serbia

[5] PJ Safarik Univ Kosice, Dept Inorgan Chem, Inst Chem, Moyzesova 11, SK-04154 Kosice, Slovakia

来源：

INORGANICA CHIMICA ACTA | 2017年 / 466卷

关键词：

Coumarine-derived ligand; Palladium(II) complex; Cytotoxicity; Crystal structure; Apoptosis; Oxidative stress; PHYSICOCHEMICAL CHARACTERIZATION; CERIUM;

D O I：

10.1016/j.ica.2017.06.015

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The new coumarine derivative, 3-(1-(3-hydroxypropylamino) ethylidene) chroman-2,4-dione, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, H-1 and C-13 NMR spectroscopy. The structure of the ligand, solved using a monocrystal X-ray structural analysis, consists of two crystallographic different pseudocentrosymmetrically related molecules of 3-(1-(3-hydroxypropylamino) ethylidene) chroman-2,4-dione, while the structure of the square-planar palladium(II) complex was proposed on the basis of DFT calculations. The palladium(II) complex decreased viability of U251 human glioma and B16 mouse melanoma cells in a dose and time dependent manner, while its ligand exhibited only moderate cytotoxicity. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：188 / 196

页数：9

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