Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease

被引:23
|
作者
Lakshmi, B. Sangeetha [1 ]
Devi, N. Harini [2 ]
Suchitra, M. M. [2 ]
Rao, P. V. L. N. Srinivasa [2 ]
Kumar, V. Siva [1 ]
机构
[1] Sri Venkateswara Inst Med Sci, Dept Nephrol, Tirupati, Andhra Prades, India
[2] Sri Venkateswara Inst Med Sci, Dept Biochem, Tirupati, Andhra Prades, India
关键词
Cardiovascular disease; hemodialysis; inflammation; oxidative stress; Pentraxin-3; CHRONIC-RENAL-FAILURE; C-REACTIVE PROTEIN; LONG PENTRAXIN PTX3; CARDIOVASCULAR-DISEASE; CLINICAL EPIDEMIOLOGY; CARDIAC-DISEASE; MORTALITY; PLASMA; ATHEROSCLEROSIS; MALNUTRITION;
D O I
10.1080/0886022X.2018.1487857
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress.
引用
收藏
页码:534 / 540
页数:7
相关论文
共 50 条
  • [21] Changes in circulating biomarkers during a single hemodialysis session
    Yamamoto, Tae
    Nascimento, Marcelo M.
    Hayashi, Shirley Y.
    Qureshi, Abdul Rashid
    Waniewski, Jacek
    Brodin, Lars Ake
    Anderstam, Bjorn
    Lind, Britta
    Riella, Miguel C.
    Seeberger, Astrid
    Lindholm, Bengt
    HEMODIALYSIS INTERNATIONAL, 2013, 17 (01) : 59 - 66
  • [22] LDL modification during hemodialysis - Markers for oxidative stress
    Sevanian, A
    Asatryan, L
    HEMODIALYSIS TECHNOLOGY, 2002, 137 : 386 - 395
  • [23] Association of Heart Rate Variability and Electrolyte Changes During Hemodialysis in Patients With Chronic Kidney Disease
    Im, Sung I.
    Hyun, Bae Su
    CIRCULATION, 2023, 148
  • [24] Oxidative stress in chronic kidney disease
    Ling X.C.
    Kuo K.-L.
    Renal Replacement Therapy, 4 (1)
  • [25] Oxidative stress in chronic kidney disease
    Kristien Daenen
    Asmin Andries
    Djalila Mekahli
    Ann Van Schepdael
    François Jouret
    Bert Bammens
    Pediatric Nephrology, 2019, 34 : 975 - 991
  • [26] OXIDATIVE STRESS OF CHRONIC KIDNEY DISEASE
    Mircescu, G.
    ACTA ENDOCRINOLOGICA-BUCHAREST, 2008, 4 (04) : 433 - 446
  • [27] Oxidative Stress in Chronic Kidney Disease
    Modaresi, Atieh
    Nafar, Mohsen
    Sahraei, Zahra
    IRANIAN JOURNAL OF KIDNEY DISEASES, 2015, 9 (03) : 165 - 179
  • [28] Oxidative Stress in Chronic Kidney Disease
    Scholze, Alexandra
    Jankowski, Joachim
    Pedraza-Chaverri, Jose
    Evenepoel, Pieter
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
  • [29] Oxidative stress and chronic kidney disease
    Brown, Scott A.
    VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 2008, 38 (01) : 157 - +
  • [30] Oxidative stress in chronic kidney disease
    Daenen, Kristien
    Andries, Asmin
    Mekahli, Djalila
    Van Schepdael, Ann
    Jouret, Francois
    Bammens, Bert
    PEDIATRIC NEPHROLOGY, 2019, 34 (06) : 975 - 991