Monoclonal gammopathy of undetermined significance: a consensus statement

被引：85

作者：

Berenson, James R. ^{[1
]}

Anderson, Kenneth C. ^{[2
]}

Audell, Robert A. ^{[3
]}

Boccia, Ralph V. ^{[4
]}

Coleman, Morton ^{[5
]}

Dimopoulos, Meletios A. ^{[6
]}

Drake, Matthew T. ^{[7
]}

Fonseca, Rafael ^{[8
]}

Harousseau, Jean-Luc ^{[9
]}

Joshua, Douglas ^{[10
]}

Lonial, Sagar ^{[11
]}

Niesvizky, Ruben ^{[5
]}

Palumbo, Antonio ^{[12
]}

Roodman, G. David ^{[13
]}

San-Miguel, Jesus F. ^{[14
]}

Singhal, Seema ^{[15
]}

Weber, Donna M. ^{[16
]}

Zangari, Maurizio ^{[17
]}

Wirtschafter, Eric ^{[1
]}

Yellin, Ori

Kyle, Robert A. ^{[18
]}

机构：

[1] Inst Myeloma & Bone Canc Res, W Hollywood, CA 90069 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[4] Ctr Canc & Blood Disorders, Bethesda, MD USA

[5] New York Presbyterian Hosp, Weill Cornell Med Coll, Div Hematol & Med Oncol, Ctr Lymphoma & Myeloma, New York, NY USA

[6] Univ Athens, Sch Med, Dept Clin Therapeut, Alexandra Hosp, GR-11527 Athens, Greece

[7] Mayo Clin, Coll Med, Div Endocrinol & Metab, Rochester, MN USA

[8] Mayo Clin Arizona, Scottsdale, AZ USA

[9] Univ Hosp Hotel Dieu, Dept Haematol, Nantes, France

[10] Royal Prince Alfred Hosp, Inst Haematol, Camperdown, NSW 2050, Australia

[11] Emory Univ, Winship Canc Ctr, Atlanta, GA 30322 USA

[12] Univ Turin, Div Ematol, Turin, Italy

[13] Vet Affairs Pittsburgh Healthcare Syst, Dept Med Hematol Oncol, Pittsburgh, PA USA

[14] Hosp Univ Salamanca, CIC, IBMCC, USAL,CSIC, Salamanca, Spain

[15] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[16] Univ Texas Houston, MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA

[17] Univ Utah, Div Hematol, Blood Marrow Transplant & Myeloma Program, Salt Lake City, UT USA

[18] Mayo Clin, Div Hematol, Rochester, MN USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 150卷 / 01期

关键词：

monoclonal gammopathy of undetermined significance; fractures; peripheral neuropathy; osteoporosis; ALPHA-LIPOIC ACID; PRECEDES MULTIPLE-MYELOMA; BONE-MINERAL DENSITY; FRACTURE RISK; DIABETIC POLYNEUROPATHY; LONG-TERM; PERIPHERAL NEUROPATHY; POSTMENOPAUSAL WOMEN; SIGNIFICANCE MGUS; RANDOMIZED-TRIAL;

D O I：

10.1111/j.1365-2141.2010.08207.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>On February 25, 2009, a panel of international experts on plasma cell dyscrasia and skeletal disease met to discuss monoclonal gammopathy of undetermined significance (MGUS). This non-malignant B-cell disorder is the most common plasma cell dyscrasia and is associated with an increased risk of developing serious B-cell disorders. Individuals with MGUS also have an increased risk of osteoporosis and osteopenia associated with an increased likelihood of developing fractures especially in the vertebral column, peripheral neuropathy and thromboembolic events. The goal of the meeting was to develop a consensus statement regarding the appropriate tests to screen, evaluate and follow-up patients with MGUS. The panel also addressed the identification and treatment of MGUS-related skeletal problems, thromboembolic events and neurological complications. The following consensus statement outlines the conclusions and marks the first time that a consensus statement for the screening and treatment of MGUS has been clearly stated.

引用

页码：28 / 38

页数：11

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