In vivo adaptation of the Wayne model of latent tuberculosis

被引：19

作者：

Woolhiser, Lisa ^{[1
]}

Tamayo, Marcela Henao ^{[1
]}

Wang, Baolin ^{[1
]}

Gruppo, Veronica ^{[1
]}

Belisle, John T. ^{[1
]}

Lenaerts, Anne J. ^{[1
]}

Basaraba, Randall J. ^{[1
]}

Orme, Ian M. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 05期

关键词：

D O I：

10.1128/IAI.00918-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cultures of Mycobacterium tuberculosis grown under oxygen depletion conditions enter into a state of nonreplicating persistence that may reflect a physiologically latent state. When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.

引用

页码：2621 / 2625

页数：5

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