Cholestane Glycosides and Trihydroxy Fatty Acids from the Rhizomes of Dioscorea septemloba

被引：14

作者：

Liu, Xue-Ting ^{[1
,2
]}

Wang, Zhen-Zhong ^{[3
]}

Xiao, Wei ^{[3
]}

Zhao, Hui-Wu ^{[3
]}

Yu, Biao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Univ Wisconsin, Dept Chem, La Crosse, WI 54601 USA

[3] Jiangsu Kan Pharmaceut Co, Jiangsu, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 03期

关键词：

Dioscorea septemloba; Dioscoreaceae; antitumor; cholestane glycoside; trihydroxy fatty acid; STEROIDAL GLYCOSIDES; CELL-LINES; CYTOTOXICITY; OXYLIPINS; SAPONINS; BULBS;

D O I：

10.1055/s-0029-1186063

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new steroidal glycosides, named dioseptemlosides I (1) and J (2), along with two known trihydroxy fatty acids, (12Z,15Z)-9,10,11-trihydroxy-12,15-octadecadienoic acid (3) and (12Z)-9,10,11-trihydroxy-12-octadecenoic acid (4), were isolated from the rhizomes of Dioscorea septemloba. Their structures were determined by HRESIMS, 1D and 2D NMR experiments, physical data, and chemical methods. The antitumor activity of compounds 1-4 was evaluated against three tumor cell lines and all of them were inactive at a concentration of 10 mu M.

引用

页码：291 / 294

页数：4

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