The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

被引：8
作者：
Ceriello, Antonio [1 ,2 ]
De Nigris, Valeria [1 ]
Pujadas, Gemma [1 ]
La Sala, Lucia [1 ,2 ,3 ]
Bonfigli, Anna Rita [4 ]
Testa, Roberto [5 ]
Uccellatore, Annachiara [3 ]
Genovese, Stefano [3 ]
机构：
[1] IDIBAPS, C Rossello 149-153, Barcelona 08036, Spain
[2] Hosp Clin Barcelona, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain
[3] IRCCS Grp Multimed, Dept Cardiovasc & Metab Dis, Sesto San Giovanni, MI, Italy
[4] INRCA Ancona, Sci Direct, Ancona, Italy
[5] INRCA IRCCS Natl Inst, Expt Models Clin Pathol, Ancona, Italy
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2016年 / 114卷
关键词：
Type; 1; diabetes; GLP-1; Endothelial function; Oxidative stress; Metabolic memory; GLUCAGON-LIKE PEPTIDE-1; OXIDATIVE STRESS; DYSFUNCTION; VASODILATATION; ACTIVATION; MELLITUS; MARKERS; CELLS;
D O I：
10.1016/j.diabres.2016.01.019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2 alpha levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：64 / 68
页数：5
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