The simultaneous control of hyperglycemia and GLP-1 infusion normalize endothelial function in type 1 diabetes

被引：8
作者：
Ceriello, Antonio [1 ,2 ]
De Nigris, Valeria [1 ]
Pujadas, Gemma [1 ]
La Sala, Lucia [1 ,2 ,3 ]
Bonfigli, Anna Rita [4 ]
Testa, Roberto [5 ]
Uccellatore, Annachiara [3 ]
Genovese, Stefano [3 ]
机构：
[1] IDIBAPS, C Rossello 149-153, Barcelona 08036, Spain
[2] Hosp Clin Barcelona, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain
[3] IRCCS Grp Multimed, Dept Cardiovasc & Metab Dis, Sesto San Giovanni, MI, Italy
[4] INRCA Ancona, Sci Direct, Ancona, Italy
[5] INRCA IRCCS Natl Inst, Expt Models Clin Pathol, Ancona, Italy
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2016年 / 114卷
关键词：
Type; 1; diabetes; GLP-1; Endothelial function; Oxidative stress; Metabolic memory; GLUCAGON-LIKE PEPTIDE-1; OXIDATIVE STRESS; DYSFUNCTION; VASODILATATION; ACTIVATION; MELLITUS; MARKERS; CELLS;
D O I：
10.1016/j.diabres.2016.01.019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: To test the effect of normoglycemia and glucagon-like peptide-1 (GLP-1), alone or in combination, on the possible normalization of endothelial function in type 1 diabetes. Methods: Fifteen people with type 1 diabetes participated in three experiments: reaching and maintaining normoglycemia for 4 h; reaching and maintaining hyperglycemia plus GLP-1 infusion for 4 h; and reaching and maintaining normoglycemia for 4 h with simultaneous infusion of GLP-1. Results: Both normoglycemia and GLP-1 infusion restored endothelial function and decreased and plasma 8-iso prostaglandin F2 alpha levels. However, only the combination of normoglycemia and GLP-1 was able to normalize endothelial function. Conclusions: This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：64 / 68
页数：5
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共 32 条
  • [1] Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics
    Andersen, FA
    [J]. INTERNATIONAL JOURNAL OF TOXICOLOGY, 2005, 24 : 51 - 111
  • [2] The ADMA-Metformin Hypothesis: Linking the Cardiovascular Consequences of the Metabolic Syndrome and Type 2 Diabetes
    Bestermann, William H., Jr.
    [J]. CARDIORENAL MEDICINE, 2011, 1 (04) : 211 - 219
  • [3] Endothelial Dysfunction Is Related to Poor Glycemic Control in Adolescents with Type 1 Diabetes under 5 Years of Disease: Evidence of Metabolic Memory
    Ce, Gislaine Vissoky
    Rohde, Luis Eduardo
    Vargas da Silva, Antonio Marcos
    Punales Coutinho, Marcia Khaled
    de Castro, Andrea Cauduro
    Bertoluci, Marcello Casaccia
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (05) : 1493 - 1499
  • [4] Simultaneous control of hyperglycemia and oxidative stress normalizes enhanced thrombin generation in type 1 diabetes
    Ceriello, A.
    Esposito, K.
    Ihnat, M.
    Zhang, J.
    Giugliano, D.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (07) : 1228 - 1230
  • [5] Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes
    Ceriello, Antonio
    Kumar, Sudhesh
    Piconi, Ludovica
    Esposito, Katerine
    Giugliano, Dario
    [J]. DIABETES CARE, 2007, 30 (03) : 649 - 654
  • [6] Simultaneous GLP-1 and Insulin Administration Acutely Enhances Their Vasodilatory, Antiinflammatory, and Antioxidant Action in Type 2 Diabetes
    Ceriello, Antonio
    Novials, Anna
    Canivell, Silvia
    La Sala, Lucia
    Pujadas, Gemma
    Esposito, Katherine
    Testa, Roberto
    Bucciarelli, Loredana
    Rondinelli, Maurizio
    Genovese, Stefano
    [J]. DIABETES CARE, 2014, 37 (07) : 1938 - 1943
  • [7] Glucagon-Like Peptide 1 Reduces Endothelial Dysfunction, Inflammation, and Oxidative Stress Induced by Both Hyperglycemia and Hypoglycemia in Type 1 Diabetes
    Ceriello, Antonio
    Novials, Anna
    Ortega, Emilio
    Canivell, Silvia
    La Sala, Lucia
    Pujadas, Gemma
    Esposito, Katherine
    Giugliano, Dario
    Genovese, Stefano
    [J]. DIABETES CARE, 2013, 36 (08) : 2346 - 2350
  • [8] The Possible Protective Role of Glucagon-Like Peptide 1 on Endothelium During the Meal and Evidence for an "Endothelial Resistance" to Glucagon-Like Peptide 1 in Diabetes
    Ceriello, Antonio
    Esposito, Katherine
    Testa, Roberto
    Bonfigli, Anna Rita
    Marra, Maurizio
    Giugliano, Dario
    [J]. DIABETES CARE, 2011, 34 (03) : 697 - 702
  • [9] Long-Term Glycemic Control Influences the Long-Lasting Effect of Hyperglycemia on Endothelial Function in Type 1 Diabetes
    Ceriello, Antonio
    Esposito, Katherine
    Ihnat, Michael
    Thorpe, Jessica
    Giugliano, Dario
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (08) : 2751 - 2756
  • [10] The "Metabolic Memory": Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?
    Ceriello, Antonio
    Ihnat, Michael A.
    Thorpe, Jessica E.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (02) : 410 - 415
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