African Mitochondrial DNA Subhaplogroups and Peripheral Neuropathy during Antiretroviral Therapy

被引:29
|
作者
Canter, Jeffrey A. [1 ,2 ]
Robbins, Gregory K. [7 ]
Selph, Doug [2 ]
Clifford, David B. [9 ]
Kallianpur, Asha R. [3 ]
Shafer, Robert [8 ]
Levy, Shawn [5 ]
Murdock, Deborah G. [1 ,2 ]
Ritchie, Marylyn D. [1 ,2 ]
Haas, David W. [4 ,6 ]
Hulgan, Todd [4 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA
[2] Vanderbilt Univ, Sch Med, Ctr Human Genet Res, Dept Med, Nashville, TN 37212 USA
[3] Vanderbilt Univ, Sch Med, Div Gen Internal Med & Publ Hlth, Nashville, TN 37212 USA
[4] Vanderbilt Univ, Sch Med, Div Infect Dis, Nashville, TN 37212 USA
[5] Vanderbilt Univ, Sch Med, Microarray Shared Resource Facil, Nashville, TN 37212 USA
[6] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37212 USA
[7] Harvard Univ, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA
[8] Stanford Univ, Dept Med Infect Dis, Stanford, CA 94305 USA
[9] Washington Univ, Sch Med, Dept Neurol & Med, St Louis, MO USA
关键词
REGION SEQUENCES; HAPLOGROUPS; DISEASE; RISK;
D O I
10.1086/652419
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.
引用
收藏
页码:1703 / 1707
页数:5
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