African Mitochondrial DNA Subhaplogroups and Peripheral Neuropathy during Antiretroviral Therapy

被引：29

作者：

Canter, Jeffrey A. ^{[1
,2
]}

Robbins, Gregory K. ^{[7
]}

Selph, Doug ^{[2
]}

Clifford, David B. ^{[9
]}

Kallianpur, Asha R. ^{[3
]}

Shafer, Robert ^{[8
]}

Levy, Shawn ^{[5
]}

Murdock, Deborah G. ^{[1
,2
]}

Ritchie, Marylyn D. ^{[1
,2
]}

Haas, David W. ^{[4
,6
]}

Hulgan, Todd ^{[4
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Ctr Human Genet Res, Dept Med, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Div Gen Internal Med & Publ Hlth, Nashville, TN 37212 USA

[4] Vanderbilt Univ, Sch Med, Div Infect Dis, Nashville, TN 37212 USA

[5] Vanderbilt Univ, Sch Med, Microarray Shared Resource Facil, Nashville, TN 37212 USA

[6] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37212 USA

[7] Harvard Univ, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA

[8] Stanford Univ, Dept Med Infect Dis, Stanford, CA 94305 USA

[9] Washington Univ, Sch Med, Dept Neurol & Med, St Louis, MO USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 11期

关键词：

REGION SEQUENCES; HAPLOGROUPS; DISEASE; RISK;

D O I：

10.1086/652419

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.

引用

页码：1703 / 1707

页数：5

共 16 条

[1] Characterization of human control region sequences of the African American SWGDAM forensic mtDNA data set [J].

Allard, MW ;

Polanskey, D ;

Miller, K ;

Wilson, MR ;

Monson, KL ;

Budowle, B .

FORENSIC SCIENCE INTERNATIONAL, 2005, 148 (2-3) :169-179

[2]

[Anonymous], 2009, GUID US ANT AG HIV 1

[3] Peripheral neuropathy and antiretroviral drugs [J].

Dalakas, MC .

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2001, 6 (01) :14-20

[4] Mitochondrial alterations with mitochondrial DNA depletion in the nerves of AIDS patients with peripheral neuropathy induced by 2′3′-dideoxycytidine (ddC) [J].

Dalakas, MC ;

Semino-Mora, C ;

Leon-Monzon, M .

LABORATORY INVESTIGATION, 2001, 81 (11) :1537-1544

[5]

Hawkins C, 2007, JAIDS-J ACQ IMM DEF, V45, P304

[6] Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups [J].

Herrnstadt, C ;

Elson, JL ;

Fahy, E ;

Preston, G ;

Turnbull, DM ;

Anderson, C ;

Ghosh, SS ;

Olefsky, JM ;

Beal, MF ;

Davis, RE ;

Howell, N .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (05) :1152-1171

[7] Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study [J].

Hulgan, T ;

Haas, DW ;

Haines, JL ;

Ritchie, MD ;

Robbins, GK ;

Shafer, RW ;

Clifford, D ;

Kallianpur, AR ;

Summar, M ;

Canter, JA .

AIDS, 2005, 19 (13) :1341-1349

[8] Modification of the incidence of drug-associated symmetrical peripheral neuropathy by host and disease factors in the HIV outpatient study cohort [J].

Lichtenstein, KA ;

Armon, C ;

Baron, A ;

Moorman, AC ;

Wood, KC ;

Holmberg, SD .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (01) :148-157

[9] Mitochondrial DNA polymorphisms associated with longevity in a Finnish population [J].

Niemi, AK ;

Hervonen, A ;

Hurme, M ;

Kurhunen, PJ ;

Jylhä, M ;

Majamaa, K .

HUMAN GENETICS, 2003, 112 (01) :29-33

[10] Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection [J].

Robbins, GK ;

De Gruttola, V ;

Shafer, RW ;

Smeaton, LM ;

Snyder, SW ;

Pettinelli, C ;

Dube, MP ;

Fischl, MA ;

Pollard, RB ;

Delapenha, R ;

Gedeon, L ;

van der Horst, C ;

Murphy, RL ;

Becker, MI ;

D'Aquila, RT ;

Vella, S ;

Merigan, TC ;

Hirsch, MS ;

Nokta, M ;

Johnson, V ;

Morse, G ;

Putnam, B ;

Klebert, M ;

Martinez, A ;

Chiesi, A ;

Tomino, C ;

Deeks, S ;

Testa, M ;

Nevin, T ;

Levin, J ;

French, V ;

Fennell, O ;

Stevens, M ;

Grosso, R ;

Dusak, B ;

Hodder, S ;

Squibb, M ;

Brothers, C ;

Tolson, J ;

Leavitt, R ;

Manion, D ;

Ruiz, N ;

Morrisey, K ;

Quart, B ;

Jennings, C ;

Dascomb, S ;

Cooper, M ;

Murphy, M ;

Blakelock, K ;

Doolan, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (24) :2293-2303

← 1 2 →