Genetics of attention-deficit/hyperactivity disorder: an update

被引：62

作者：

Akutagava-Martins, Glaucia Chiyoko ^{[1
]}

Rohde, Luis Augusto ^{[2
,3
]}

Hutz, Mara Helena ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil

[2] Hosp Clin Porto Alegre, Child & Adolescent Psychiat Div, Porto Alegre, RS, Brazil

[3] Inst Dev Psychiat Children & Adolescents INCT CNP, Porto Alegre, RS, Brazil

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2016年 / 16卷 / 02期

关键词：

susceptibility; CNVs; ADHD; genetics; pathway analysis; polygenic risk score analysis; GWAS; DEFICIT HYPERACTIVITY DISORDER; GENOME-WIDE-ASSOCIATION; COPY NUMBER VARIANTS; RARE VARIANTS; DE-NOVO; HYPERACTIVE/IMPULSIVE SYMPTOMS; MOLECULAR-GENETICS; GENERAL-POPULATION; BIPOLAR DISORDER; POLYGENIC RISK;

D O I：

10.1586/14737175.2016.1130626

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder affecting children, adolescents, and adults. The prevalence is estimated at 5 to 7% of school-aged children and 2.5 to 5% of adults. The phenotype is complex and heterogeneous, presenting variable clinical features, developmental course, and outcome. The genetic susceptibility to ADHD is attributed to both common and rare variants from a broad range of genes related mainly to neurotransmission and neurodevelopment pathways. However, it has been difficult to identify the genetic risk variants that account for the high heritability of this disorder. In this paper, we present recent findings from molecular genetics studies on both child and adult ADHD. Challenges and future directions for ADHD genetic studies are reviewed and discussed.

引用

页码：145 / 156

页数：12

共 110 条

[41] Functional Gene-Set Analysis Does Not Support a Major Role for Synaptic Function in Attention Deficit/Hyperactivity Disorder (ADHD) [J].

Hammerschlag, Anke R. ;

Polderman, Tinca J. C. ;

de Leeuw, Christiaan ;

Tiemeier, Henning ;

White, Tonya ;

Smit, August B. ;

Verhage, Matthijs ;

Posthuma, Danielle .

GENES, 2014, 5 (03) :604-614

[42] Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia [J].

Hamshere, Marian L. ;

Stergiakouli, Evangelia ;

Langley, Kate ;

Martin, Joanna ;

Holmans, Peter ;

Kent, Lindsey ;

Owen, Michael J. ;

Gill, Michael ;

Thapar, Anita ;

O'Donovan, Mick ;

Craddock, Nick .

BRITISH JOURNAL OF PSYCHIATRY, 2013, 203 (02) :107-111

[43] High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression [J].

Hamshere, Marian L. ;

Langley, Kate ;

Martin, Joanna ;

Agha, Sharifah Shameem ;

Stergiakouli, Evangelia ;

Anney, Richard J. L. ;

Buitelaar, Jan ;

Faraone, Stephen V. ;

Lesch, Klaus-Peter ;

Neale, Benjamin M. ;

Franke, Barbara ;

Sonuga-Barke, Edmund J. S. ;

Asherson, Philip ;

Merwood, Andrew ;

Kuntsi, Jonna ;

Medland, Sarah E. ;

Ripke, Stephan ;

Steinhausen, Hans-Christoph ;

Freitag, Christine ;

Reif, Andreas ;

Renner, Tobias J. ;

Romanos, Marcel ;

Romanos, Jasmin ;

Warnke, Andreas ;

Meyer, Jobst ;

Palmason, Haukur ;

Vasquez, Alejandro Arias ;

Lambregts-Rommelse, Nanda ;

Roeyers, Herbert ;

Biederman, Joseph ;

Doyle, Alysa E. ;

Hakonarson, Hakon ;

Rothenberger, Aribert ;

Banaschewski, Tobias ;

Oades, Robert D. ;

McGough, James J. ;

Kent, Lindsey ;

Williams, Nigel ;

Owen, Michael J. ;

Holmans, Peter ;

O'Donovan, Michael C. ;

Thapar, Anita .

AMERICAN JOURNAL OF PSYCHIATRY, 2013, 170 (08) :909-916

[44] DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder [J].

Havik, Bjarte ;

Degenhardt, Franziska A. ;

Johansson, Stefan ;

Fernandes, Carla P. D. ;

Hinney, Anke ;

Scherag, Andre ;

Lybaek, Helle ;

Djurovic, Srdjan ;

Christoforou, Andrea ;

Ersland, Kari M. ;

Giddaluru, Sudheer ;

O'Donovan, Michael C. ;

Owen, Michael J. ;

Craddock, Nick ;

Muehleisen, ThomasW. ;

Mattheisen, Manuel ;

Schimmelmann, Benno G. ;

Renner, Tobias ;

Warnke, Andreas ;

Herpertz-Dahlmann, Beate ;

Sinzig, Judith ;

Albayrak, Oezguer ;

Rietschel, Marcella ;

Noethen, Markus M. ;

Bramham, Clive R. ;

Werge, Thomas ;

Hebebrand, Johannes ;

Haavik, Jan ;

Andreassen, Ole A. ;

Cichon, Sven ;

Steen, Vidar M. ;

Le Hellard, Stephanie .

PLOS ONE, 2012, 7 (04)

[45] Genome-Wide Association Study in German Patients With Attention Deficit/Hyperactivity Disorder [J].

Hinney, Anke ;

Scherag, Andre ;

Jarick, Ivonne ;

Albayrak, Oezguer ;

Puetter, Carolin ;

Pechlivanis, Sonali ;

Dauvermann, Maria R. ;

Beck, Sebastian ;

Weber, Heike ;

Scherag, Susann ;

Nguyen, Trang T. ;

Volckmar, Anna-Lena ;

Knoll, Nadja ;

Faraone, Stephen V. ;

Neale, Benjamin M. ;

Franke, Barbara ;

Cichon, Sven ;

Hoffmann, Per ;

Noethen, Markus M. ;

Schreiber, Stefan ;

Joeckel, Karl-Heinz ;

Wichmann, H. -Erich ;

Freitag, Christine ;

Lempp, Thomas ;

Meyer, Jobst ;

Gilsbach, Susanne ;

Herpertz-Dahlmann, Beate ;

Sinzig, Judith ;

Lehmkuhl, Gerd ;

Renner, Tobias J. ;

Warnke, Andreas ;

Romanos, Marcel ;

Lesch, Klaus-Peter ;

Reif, Andreas ;

Schimmelmann, Benno G. ;

Hebebrand, Johannes .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2011, 156B (08) :888-897

[46] Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders [J].

Hiroi, N. ;

Takahashi, T. ;

Hishimoto, A. ;

Izumi, T. ;

Boku, S. ;

Hiramoto, T. .

MOLECULAR PSYCHIATRY, 2013, 18 (11) :1153-1165

[47] Acetylcholine-metabolizing butyrylcholinesterase (BCHE) copy number and single nucleotide polymorphisms and their role in attention-deficit/hyperactivity syndrome [J].

Jacob, Christian P. ;

Weber, Heike ;

Retz, Wolfgang ;

Kittel-Schneider, Sarah ;

Heupel, Julia ;

Renner, Tobias ;

Lesch, Klaus-Peter ;

Reif, Andreas .

JOURNAL OF PSYCHIATRIC RESEARCH, 2013, 47 (12) :1902-1908

[48] Evaluation of several micro RNA (miRNA) levels in children and adolescents with attention deficit hyperactivity disorder [J].

Kandemir, Hasan ;

Erdal, Mehmet Emin ;

Selek, Salih ;

Ay, Ozlem Izci ;

Karababa, Ibrahim Fatih ;

Kandemir, Sultan Basmaci ;

Ay, Mustafa Ertan ;

Yilmaz, Senay Gorucu ;

Bayazit, Huseyin ;

Tasdelen, Bahar .

NEUROSCIENCE LETTERS, 2014, 580 :158-162

[49] Endophenotype: a conceptual analysis [J].

Kendler, K. S. ;

Neale, M. C. .

MOLECULAR PSYCHIATRY, 2010, 15 (08) :789-797

[50] Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs [J].

Larsson, Henrik ;

Anckarsater, Henrik ;

Rastam, Maria ;

Chang, Zheng ;

Lichtenstein, Paul .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2012, 53 (01) :73-80

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