Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

被引：5

作者：

Lau, Sophie ^{[1
]}

Stanhope, Naomi ^{[1
]}

Griffin, John ^{[1
]}

Hughes, Eleri ^{[1
]}

Middleton, David A. ^{[1
]}

机构：

[1] Univ Lancaster, Dept Chem, Lancaster LA1 4YB, England

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 88期

基金：

英国工程与自然科学研究理事会;

关键词：

HIGH-DENSITY-LIPOPROTEIN; SCAVENGER RECEPTOR; LATERAL DIFFUSION; MODEL MEMBRANES; CLINICAL-TRIALS; CLASS-B; CHOLESTEROL;

D O I：

10.1039/c9cc05344a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR measurements of F-19 chemical shift anisotropy and H-1-F-19 dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.

引用

页码：13287 / 13290

页数：4

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