Chemical Exchanges between Multilateral Symbionts

被引：17

作者：

Bae, Munhyung ^{[1
]}

Mevers, Emily ^{[1
]}

Pishchany, Gleb ^{[1
]}

Whaley, Sarah G. ^{[2
]}

Rock, Charles O. ^{[2
]}

Andes, David R. ^{[3
]}

Currie, Cameron R. ^{[4
]}

Pupo, Monica T. ^{[5
]}

Clardy, Jon ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[3] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53705 USA

[4] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[5] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 05期

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会;

关键词：

D O I：

10.1021/acs.orglett.1c00068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.

引用

页码：1648 / 1652

页数：5

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