In vitro cytotoxicity of decabrominated diphenyl ether (PBDE-209) to human red blood cells (hRBCs)

被引：17

作者：

Chi, Zhenxing ^{[1
,2
,3
]}

Tan, Songwen ^{[1
]}

Li, Weiguo ^{[1
]}

Wen, Zhengzhong ^{[1
]}

Song, Xuemei ^{[4
]}

Wang, Mingjing ^{[4
]}

机构：

[1] Harbin Inst Technol, Sch Marine Sci & Technol, 2 Wenhua West Rd, Weihai 264209, Peoples R China

[2] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, 73 Huanghe Rd, Harbin 150090, Peoples R China

[3] Jinan Univ, Sch Environm, Guangzhou Key Lab Environm Exposure & Hlth, Guangzhou 510632, Guangdong, Peoples R China

[4] Weihai Blood Ctr, 28 Qingdao North Rd, Weihai 264200, Peoples R China

来源：

CHEMOSPHERE | 2017年 / 180卷

基金：

中国博士后科学基金;

关键词：

Decabrominated diphenyl ether; Human; Red blood cells; Cytotoxicity; LIPID-PEROXIDATION; OXIDATIVE STRESS; STURNUS-VULGARIS; FLAME RETARDANTS; PBDES; EXPOSURE; CHINA; DISRUPTION; TRANSPORT; TOXICITY;

D O I：

10.1016/j.chemosphere.2017.04.032

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This work presents the effect of decabrominated diphenyl ether (PBDE-209) on the anti-oxidative defense capacity, and ATPase activity (structure and function) of human red blood cells (hRBCs). The results show that the PBDE-209 influences the activity and content of typical biomolecules (SOD, CAT, GSH-Px, GSH and MDA) in hRBCs, causing a decline in the function of the antioxidant defense system. The PBDE-209 with a concentration of 10 mu mol/L resulted in the cytoplasmic projections and structure deformation of the hRBCs. When its concentration exceeds 25 mu mol/L, the relative ATPase activity was decreased to 20% of the initial activity. Since the discovered effects of PBDE-209 on hRBCs are in cell level, this study may offer some information to advise the related in vivo cytotoxicity works. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：312 / 316

页数：5

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