Novel methodologies in analysis of small molecule biomarkers and living cells

被引：7

作者：

Chen, Yinan ^{[1
]}

Zhu, Zhenggang ^{[1
]}

Yu, Yingyan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Gastr Neoplasms, Shanghai Ruijin Hosp, Dept Surg,Shanghai Inst Digest Surg,Sch Med, Shanghai 200025, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Biomarkers; Quantitative immuno-PCR; Chromatography-mass spectrometry; Nucleic acid aptamer; SOLID-PHASE MICROEXTRACTION; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; IN-VITRO SELECTION; IMMUNO-PCR; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; MASS-SPECTROMETRY; SYSTEMATIC EVOLUTION; COLORECTAL-CANCER; BLADDER-CANCER;

D O I：

10.1007/s13277-014-2439-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Enzyme-linked immuno-sorbent assay (ELISA) is widely used for biomarker detection. A good biomarker can distinguish patients from healthy or benign diseases. However, the ELISA method is not suitable for small molecule or trace substance detection. Along with the development of new technologies, an increasing level of biomaterials, especially small molecules, will be identified as novel biomarkers. Quantitative immuno-PCR, chromatography-mass spectrometry, and nucleic acid aptamer are emerging methodologies for detection of small molecule biomarkers, even in living cells. In this review, we focus on these novel technologies and their potential for small molecule biomarkers and living cell analysis.

引用

页码：9469 / 9477

页数：9

共 82 条

[1] New Dual Monoclonal ELISA for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple ELISAs [J].

Anborgh, Pieter H. ;

Wilson, Sylvia M. ;

Tuck, Alan B. ;

Winquist, Eric ;

Schmidt, Nancy ;

Hart, Russell ;

Kon, Shigeyuki ;

Maeda, Masahiro ;

Uede, Toshimitsu ;

Stitt, Larry W. ;

Chambers, Ann F. .

CLINICAL CHEMISTRY, 2009, 55 (05) :895-903

[2] Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors [J].

Arlt, Wiebke ;

Biehl, Michael ;

Taylor, Angela E. ;

Hahner, Stefanie ;

Libe, Rossella ;

Hughes, Beverly A. ;

Schneider, Petra ;

Smith, David J. ;

Stiekema, Han ;

Krone, Nils ;

Porfiri, Emilio ;

Opocher, Giuseppe ;

Bertherat, Jerome ;

Mantero, Franco ;

Allolio, Bruno ;

Terzolo, Massimo ;

Nightingale, Peter ;

Shackleton, Cedric H. L. ;

Bertagna, Xavier ;

Fassnacht, Martin ;

Stewart, Paul M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (12) :3775-3784

[3] Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS [J].

Baniasadi, Hamid ;

Gowda, G. A. Nagana ;

Gu, Haiwei ;

Zeng, Ao ;

Zhuang, Shui ;

Skill, Nicholas ;

Maluccio, Mary ;

Raftery, Daniel .

ELECTROPHORESIS, 2013, 34 (19) :2910-2917

[4] Oxidative Stress Measured by Urine F2-Isoprostane Level is Associated With Prostate Cancer [J].

Barocas, Daniel A. ;

Motley, Saundra ;

Cookson, Michael S. ;

Chang, Sam S. ;

Penson, David F. ;

Dai, Qi ;

Milne, Ginger ;

Roberts, L. Jackson, II ;

Morrow, Jason ;

Concepcion, Raoul S. ;

Smith, Joseph A., Jr. ;

Fowke, Jay H. .

JOURNAL OF UROLOGY, 2011, 185 (06) :2102-2107

[5] Determination of nicotine and cotinine in human serum by means of LC/MS [J].

Baumann, F. ;

Regenthal, R. ;

Burgos-Guerrero, I. L. ;

Hegerl, U. ;

Preiss, R. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2010, 878 (01) :107-111

[6]

Borgoño CA, 2003, CANCER RES, V63, P9032

[7] Investigation of lung cancer biomarkers by hyphenated separation techniques and chemometrics [J].

Buszewski, Boguslaw ;

Ulanowska, Agnieszka ;

Kowalkowski, Tomasz ;

Cieslinski, Krzysztof .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2012, 50 (03) :573-581

[8] Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method [J].

Chen, Feng ;

Xue, Jihua ;

Zhou, Linfu ;

Wu, Shanshan ;

Chen, Zhi .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 401 (06) :1899-1904

[9] Real-time immuno-PCR assay for detecting PCBs in soil samples [J].

Chen, Han-Yu ;

Zhuang, Hui-Sheng .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 394 (04) :1205-1211

[10] Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook. f. [J].

Chen, Minjun ;

Ni, Yan ;

Duan, Hongquan ;

Qiu, Yunping ;

Guo, Congying ;

Jiao, Yang ;

Shi, Huijuan ;

Su, Mingming ;

Jia, Wei .

CHEMICAL RESEARCH IN TOXICOLOGY, 2008, 21 (02) :288-294

← 1 2 3 4 5 6 7 8 9 →