Glucose-lowering drugs with cardiovascular benefits as modifiers of critical elements of the human life history

被引：8

作者：

Avogaro, Angelo ^{[1
]}

de Kreutzenberg, Saula Vigili ^{[1
]}

Morieri, Mario Luca ^{[1
]}

Fadini, Gian Paolo ^{[1
]}

Del Prato, Stefano ^{[2
]}

机构：

[1] Univ Padua, Sect Diabet & Metab Dis, Dept Med, Padua, Italy

[2] Univ Pisa, Sect Diabet & Metab Dis, Dept Clin & Expt Med, Pisa, Italy

来源：

LANCET DIABETES & ENDOCRINOLOGY | 2022年 / 10卷 / 12期

关键词：

GESTATIONAL DIABETES-MELLITUS; PEPTIDE-1; ANALOG; OXIDATIVE STRESS; CHRONIC INFLAMMATION; RECEPTOR AGONISTS; HEART-FAILURE; OBESITY; RISK; MORTALITY; DISEASE;

D O I：

10.1016/S2213-8587(22)00247-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The life history theory assumes that all organisms are under selective pressure to harvest external resources and allocate them to maximise fitness: only organisms making the best use of energy obtain the greatest fitness benefits. The trade-off of energy spans four functions: maintenance, growth, reproduction, and defence against pathogens. The innovative antihyperglycaemic agents glucagon-like peptide 1 (GLP-1) receptor agonists and sodium-glucose cotransporter 2 (SGLT2) inhibitors decrease bodyweight and have the potential to counter low-grade inflammation. These key activities could rewire two components of the life history theory operative in adulthood-ie, maintenance and defence. In this Personal View, we postulate that the benefits of these medications on the cardiovascular system, beyond their glucose-lowering effects, could be mediated by the reduction of the maintenance cost driven by obesity and efforts spent on blunting low-grade inflammation.

引用

页码：882 / 889

页数：8

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