Attenuated total reflection Fourier transform infrared spectroscopy for on-chip monitoring of solute concentrations

被引：45
作者：
Greener, Jesse [1 ]
Abbasi, Bardia [1 ]
Kumacheva, Eugenia [1 ]
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
LAB ON A CHIP | 2010年 / 10卷 / 12期
基金：
加拿大自然科学与工程研究理事会;
关键词：
ATR-FTIR SPECTROSCOPY; MICROFLUIDIC SYSTEMS; CONFORMATIONAL-CHANGES; RAMAN-SPECTROSCOPY; DEVICE; WATER; IR; CHROMATOGRAPHY; ORIENTATION; INTERFACE;
D O I：
10.1039/c001889a
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We report a cost-efficient Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR) method for monitoring concentrations of solutes in solutions flowing through microfluidic channels. The method allows rapid acquisition of spectra and enables chemical characterisation and concentration measurements that are independent of the flow rate of liquids. The method enables independent measurement of concentrations of solutes with distinct spectral features in mixed solutions. For the polymer solutes studied in the present work, the method has a sensitivity of at least 10 mu M(0.01 wt%). We also propose the applicability of the method for the differentiation between dissolved and adsorbed amphiphilic species.
引用
收藏
页码：1561 / 1566
页数：6
相关论文
共 51 条
  • [1] Acha V, 2000, BIOTECHNOL BIOENG, V68, P473, DOI 10.1002/(SICI)1097-0290(20000605)68:5<473::AID-BIT1>3.0.CO
  • [2] 2-8
  • [3] [Anonymous], 1985, The Aldrich Library of FT-IR Spectra
  • [4] Effective path length in attenuated total reflection spectroscopy
    Averett, Lacey A.
    Griffiths, Peter R.
    Hishikida, Koichi
    [J]. ANALYTICAL CHEMISTRY, 2008, 80 (08) : 3045 - 3049
  • [5] EFFECT OF THE NONIONIC DETERGENT TRITON X-100 ON MITOCHONDRIAL SUCCINATE-OXIDIZING ENZYMES
    BARBERO, MC
    VALPUESTA, JM
    RIAL, E
    GURTUBAY, JIG
    GONI, FM
    MACARULLA, JM
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 228 (02) : 560 - 568
  • [6] A Microfluidic High-Resolution NMR Flow Probe
    Bart, Jacob
    Kolkman, Ard J.
    Oosthoek-de Vries, Anna Jo
    Koch, Kaspar
    Nieuwland, Pieter J.
    Janssen, Hans
    van Bentum, P. J. M.
    Ampt, Kirsten A. M.
    Rutjes, Floris P. J. T.
    Wijmenga, Sybren S.
    Gardeniers, Han
    Kentgens, Arno P. M.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (14) : 5014 - +
  • [7] Kinetics of conformational changes of fibronectin adsorbed onto model surfaces
    Baujard-Lamotte, L.
    Noinville, S.
    Goubard, F.
    Marque, P.
    Pauthe, E.
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2008, 63 (01) : 129 - 137
  • [8] Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection
    Benetton, S
    Kameoka, J
    Tan, AM
    Wachs, T
    Craighead, H
    Henion, JD
    [J]. ANALYTICAL CHEMISTRY, 2003, 75 (23) : 6430 - 6436
  • [9] The Continuous-Flow Synthesis of Ibuprofen
    Bogdan, Andrew R.
    Poe, Sarah L.
    Kubis, Daniel C.
    Broadwater, Steven J.
    McQuade, D. Tyler
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (45) : 8547 - 8550
  • [10] CONSISTENCY IN CIRCLE CELL FT-IR ANALYSIS OF AQUEOUS-SOLUTIONS
    BRAUE, EH
    PANNELLA, MG
    [J]. APPLIED SPECTROSCOPY, 1987, 41 (06) : 1057 - 1067
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