Critical analysis of nonitiflammatory treatments of sepsis: lessons learned from previous trials

被引：0
作者：
Montravers, P. [1 ]
Lasocki, S.
Seguin, P.
Malledant, Y.
机构：
[1] Univ Paris 07, Assistance Publ Hop Paris, CHU Bichat Claude Bernard, Dept Anesthesie Reanimat Chirurg, F-75018 Paris, France
[2] Hop Pontchaillou, Serv Reanimat Chirurg 1, Samu, F-35033 Rennes, France
来源：
ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 2007年 / 26卷 / 04期
关键词：
septic shock; severe sepsis; clinical trials; randomization; methodological bias; inclusion criteria; evaluation criteria;
D O I：
10.1016/j.annfar.2007.01.015
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
A large number of immunomodulatory therapies has been evaluated in patients with severe sepsis and septic shock. Until recently, none of these treatments has ever demonstrated any benefit in terms of decreased mortality. Many biases could interfere with the results of these clinical trials linked to poor comprehension of immune response, pharmacological errors, selection bias, and mistakes in the evaluation of the patients and in the interpretation of the results. Based on these methodological flaws, the authors try to define directions for future clinical trials. (c) 2007 Elsevier Masson SAS. Tous droits reserves.
引用
收藏
页码：363 / 369
页数：7
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