E3 ubiquitin ligases as novel targets for inflammatory diseases

被引：30
作者：
Goru, Santosh Kumar [1 ]
Pandey, Anuradha [1 ]
Gaikwad, Anil Bhanudas [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Pharm, Mol Pharmacol Lab, Pilani Campus, Pilani 333031, Rajasthan, India
来源：
PHARMACOLOGICAL RESEARCH | 2016年 / 106卷
关键词：
Inflammation; Ubiquitination; E3 ubiquitin ligase; Metabolic disorders; Asthma; Cardiac inflammation; NF-KAPPA-B; OBESITY-INDUCED INFLAMMATION; NECROSIS-FACTOR-ALPHA; CBL-B; INSULIN-RESISTANCE; TH2; CYTOKINES; LINEAR UBIQUITINATION; MEDIATED PROTEOLYSIS; PROTEASOME PATHWAY; ADIPOSE-TISSUE;
D O I：
10.1016/j.phrs.2016.02.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ubiquitination is one of the post translational modifications which decide the fate of various proteins in the cells, by either directing them towards proteasomal degradation or participation in several cell signalling pathways. Recently, the role of ubiquitination has been unravelled in pathogenesis and progression of various diseases, where inflammation is critical, like obesity, insulin resistance, atherosclerosis, angiotensin-II induced cardiac inflammation and asthma. E3 ligases are known to be instrumental in regulation of the inflammatory cascade. This review focuses on the role of different E3 ligases in the development of inflammatory diseases and thus may help us to target these E3 ligases in future drug discovery to prevent inflammation. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 97 条
[1]   Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [J].
Abe, Tomoki ;
Hirasaka, Katsuya ;
Kohno, Shohei ;
Ochi, Arisa ;
Yamagishi, Naoko ;
Ohno, Ayako ;
Teshima-Kondo, Shigetada ;
Nikawa, Takeshi .
ENDOCRINE JOURNAL, 2014, 61 (06) :529-538
[2]   Cbl-b Is a Critical Regulator of Macrophage Activation Associated With Obesity-Induced Insulin Resistance in Mice [J].
Abe, Tomoki ;
Hirasaka, Katsuya ;
Kagawa, Sachiko ;
Kohno, Shohei ;
Ochi, Arisa ;
Utsunomiya, Kenro ;
Sakai, Atsuko ;
Ohno, Ayako ;
Teshima-Kondo, Shigetada ;
Okumura, Yuushi ;
Oarada, Motoko ;
Maekawa, Yoichi ;
Terao, Junji ;
Mills, Edward M. ;
Nikawa, Takeshi .
DIABETES, 2013, 62 (06) :1957-1969
[3]  
[Anonymous], INT IMMUNOL
[4]  
[Anonymous], IMMUN RES
[5]  
[Anonymous], SCI REP
[6]  
[Anonymous], E J CARDIOL
[7]  
[Anonymous], ANN HEPATOL
[8]  
[Anonymous], BIOMED RES INT
[9]   NF-κB, Inflammation, and Metabolic Disease [J].
Baker, Rebecca G. ;
Hayden, Matthew S. ;
Ghosh, Sankar .
CELL METABOLISM, 2011, 13 (01) :11-22
[10]   Th2 cytokines and asthma: an introduction [J].
Barnes, PJ .
RESPIRATORY RESEARCH, 2001, 2 (02) :64-65
12345678910