Untangling the structure of the TDP-43 N-terminal domain

被引:8
作者
Chang, Chung-ke [1 ]
Huang, Tai-huang [1 ]
机构
[1] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
关键词
NEURODEGENERATIVE DISEASES; PROTEIN; BINDING;
D O I
10.1111/febs.13676
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1239 / 1241
页数:3
相关论文
共 16 条
  • [1] TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain
    Budini, Mauricio
    Romano, Valentina
    Quadri, Zainuddin
    Buratti, Emanuele
    Baralle, Francisco E.
    [J]. HUMAN MOLECULAR GENETICS, 2015, 24 (01) : 9 - 20
  • [2] Targeting TDP-43 in neurodegenerative diseases
    Budini, Mauricio
    Baralle, Francisco E.
    Buratti, Emanuele
    [J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2014, 18 (06) : 617 - 632
  • [3] TDP-43: gumming up neurons through protein-protein and protein-RNA interactions
    Buratti, Emanuele
    Baralle, Francisco E.
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2012, 37 (06) : 237 - 247
  • [4] The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity
    Chang, Chung-ke
    Wu, Tzong-Huah
    Wu, Chu-Ya
    Chiang, Ming-hui
    Toh, Elsie Khai-Woon
    Hsu, Yin-Chih
    Lin, Ku-Feng
    Liao, Yu-heng
    Huang, Tai-huang
    Huang, Joseph Jen-Tse
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 425 (02) : 219 - 224
  • [5] Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy
    Clippinger, Amy K.
    D'Alton, Simon
    Lin, Wen-Lang
    Gendron, Tania F.
    Howard, John
    Borchelt, David R.
    Cannon, Ashley
    Carlomagno, Yari
    Chakrabarty, Paramita
    Cook, Casey
    Golde, Todd E.
    Levites, Yona
    Ranum, Laura
    Schultheis, Patrick J.
    Xu, Guilian
    Petrucelli, Leonard
    Sahara, Naruhiko
    Dickson, Dennis W.
    Giasson, Benoit
    Lewis, Jada
    [J]. ACTA NEUROPATHOLOGICA, 2013, 126 (01) : 39 - 50
  • [6] Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
    Freibaum, Brian D.
    Chitta, Raghu K.
    High, Anthony A.
    Taylor, J. Paul
    [J]. JOURNAL OF PROTEOME RESEARCH, 2010, 9 (02) : 1104 - 1120
  • [7] Gammon Katharine, 2014, Nature, V515, P299
  • [8] CLONING AND CHARACTERIZATION OF A NOVEL CELLULAR PROTEIN, TDP-43, THAT BINDS TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAR DNA-SEQUENCE MOTIFS
    IGNATIUS, SH
    WU, F
    HARRICH, D
    GARCIAMARTINEZ, LF
    GAYNOR, RB
    [J]. JOURNAL OF VIROLOGY, 1995, 69 (06) : 3584 - 3596
  • [9] Practically Useful: What the ROSETTA Protein Modeling Suite Can Do for You
    Kaufmann, Kristian W.
    Lemmon, Gordon H.
    DeLuca, Samuel L.
    Sheehan, Jonathan H.
    Meiler, Jens
    [J]. BIOCHEMISTRY, 2010, 49 (14) : 2987 - 2998
  • [10] The TDP-43 N-terminal domain structure at high resolution
    Mompean, Miguel
    Romano, Valentina
    Pantoja-Uceda, David
    Stuani, Cristiana
    Baralle, Francisco E.
    Buratti, Emanuele
    Laurents, Douglas V.
    [J]. FEBS JOURNAL, 2016, 283 (07) : 1242 - 1260