Intra-arterial Hepatic Chemotherapy, Chemoembolisation and Radioembolisation: a Significant Contribution in the Treatment of Colorectal Cancer Liver Metastases

被引：0

作者：

Pernot, S. ^{[1
]}

Pellerin, O. ^{[2
]}

Ghazzar, N. ^{[3
]}

Vaillant, J. N. ^{[1
]}

Lepere, C. ^{[1
]}

Sapoval, M. ^{[2
]}

Taieb, J. ^{[1
]}

Rougier, P. ^{[1
]}

机构：

[1] Univ Paris 05, CHU Georges Pompidou HEGP, Assistance Publ Hop Paris, Serv HGE & Oncol Digest, F-75015 Paris, France

[2] Univ Paris 05, CHU Georges Pompidou HEGP, Assistance Publ Hop Paris, Serv Radiol Intervent, F-75015 Paris, France

[3] Univ Paris 05, CHU Georges Pompidou HEGP, Assistance Publ Hop Paris, Dept Med Nucl, F-75015 Paris, France

来源：

ONCOLOGIE | 2014年 / 16卷 / 11-12期

关键词：

Hepatic arterial infusion; Hepatic intra-arterial chemotherapy; Chemoembolisation; Radioembolisation; Colorectal cancers; Liver metastases; Y-90 RESIN MICROSPHERES; ARTERIAL INFUSION; SYSTEMIC CHEMOTHERAPY; COMPLETE RESPONSE; RANDOMIZED-TRIAL; PHASE-II; OXALIPLATIN; IRINOTECAN; RESECTION; RADIOEMBOLIZATION;

D O I：

10.1007/s10269-014-2468-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Local treatment of liver metastases (LM) of colorectal adenocarcinomas (CRC) has an emerging role in strategies of treatment for patients with limited or predominant unresectable LM. Hepatic intra-arterial chemotherapy (HIAC) demonstrated efficacy. Its combination with systemic chemotherapy allowed to double the response rate, and increased the rate of secondary resection and survival of patients. The effectiveness of chemoembolization (CE) and radio-embolization (RE) was primarily established from Phase II or Phase III evaluation of patients in very advanced stages, and progression-free survival and overall survival were increased. The role of these treatments at earlier stages is being evaluated and is expected to optimize the care of patients with LM. These local treatments must now be used in combination with effective systemic therapies, and/or resection, and the choice of the best strategies and protocols must be done in specialized team with collaboration of expert radiologist, nuclear medicine and oncologist.

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页码：S571 / S578

页数：8

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