Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury

被引：77

作者：

Chamoun, F ^{[1
]}

Burne, M ^{[1
]}

O'Donnell, M ^{[1
]}

Rabb, H ^{[1
]}

机构：

[1] Univ Minnesota, Hennepin Cty Med Ctr, Sch Med, Div Nephrol, Minneapolis, MN 55415 USA

来源：

FRONTIERS IN BIOSCIENCE | 2000年 / 5卷

关键词：

selectin; selectin ligands; leukocyte adhesion molecules; ischemia-reperfusion; review;

D O I：

10.2741/chamoun

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research findings are unveiling the potential role of leukocytes and leukocyte adhesion molecules such as selectins in ischemia-reperfusion injury (IRI). "Anti-adhesion" therapy using selectin blocking agents may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs, including transplantation, reperfusion after thrombotic events and shock. In this paper we review the pathophysiology of IRI, the different types of selectins and selectin ligands, the clinical implications of selectin blockade in different organs with IRI, and new insights into mechanism of action.

引用

页码：E103 / E109

页数：7