Childhood bone mass acquisition and peak bone mass may not be important determinants of bone mass in late adulthood

被引:52
作者
Gafni, Rachel I.
Baron, Jeffrey [1 ]
机构
[1] NICHHD, Sect Growth & Dev, Dev Endocrinol Branch, NIH, Bethesda, MD 20892 USA
[2] Univ Maryland, Sch Med, Dept Pediat, Baltimore, MD 21201 USA
关键词
bone mass acquisition; childhood; adolescence; peak bone mass;
D O I
10.1542/peds.2006-2023D
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
During childhood and adolescence, bone mass acquisition occurs primarily through skeletal growth. It is widely assumed that bone mass acquisition throughout childhood is an important determinant of the risk of osteoporosis in late adulthood; bone mass is thought to resemble a bank account in which deposits persist indefinitely. However, several well- controlled clinical studies suggest that increasing bone mass acquisition during childhood will have only transient effects. A likely explanation is that bone mass is governed by a homeostatic system that tends to return to a set point after any perturbation and, therefore, bone mass depends primarily on recent conditions, not those in the distant past. Indeed, in an animal model, we have shown evidence that bone mass acquisition in early life has no effect on bone mass in adulthood, in part because many areas of the juvenile skeleton are replaced in toto through skeletal growth. Therefore, it should not be assumed that alterations in childhood bone mass acquisition will affect bone mass many decades later in late adulthood. This issue remains open and the solution may depend on the type of childhood condition (for example calcium intake versus exercise) and its magnitude, timing, and duration. To date, both animal studies and clinical studies suggest that much of the effect of early bone mass acquisition does not persist.
引用
收藏
页码:S131 / S136
页数:6
相关论文
共 26 条
[1]  
[Anonymous], 2004, Bone Health and Osteoporosis: A report of the Surgeon General
[2]   One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis [J].
Black, DM ;
Bilezikian, JP ;
Ensrud, KE ;
Greenspan, SL ;
Palermo, L ;
Hue, T ;
Lang, TF ;
McGowan, JA ;
Rosen, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (06) :555-565
[3]   Calcium-enriched foods and bone mass growth in prepubertal girls: A randomized, double-blind, placebo-controlled trial [J].
Bonjour, JP ;
Carrie, AL ;
Ferrari, S ;
Clavien, H ;
Slosman, D ;
Theintz, G ;
Rizzoli, R .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1287-1294
[4]   Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study [J].
Bonjour, JP ;
Chevalley, T ;
Ammann, P ;
Slosman, D ;
Rizzoli, R .
LANCET, 2001, 358 (9289) :1208-1212
[5]   Mechanisms responsible for longitudinal growth of the cortex: Coalescence of trabecular bone into cortical bone [J].
Cadet, ER ;
Gafni, RI ;
McCarthy, EF ;
McCray, DR ;
Bacher, JD ;
Barnes, KM ;
Baron, J .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2003, 85A (09) :1739-1748
[6]   Interaction between calcium intake and menarcheal age on bone mass gain: An eight-year follow-up study from prepuberty to postmenarche [J].
Chevalley, T ;
Rizzoli, R ;
Hans, D ;
Ferrari, S ;
Bonjour, JP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (01) :44-51
[7]   Catch-up growth: Testing the hypothesis of delayed growth plate senescence in humans [J].
Emons, JAM ;
Boersma, B ;
Baron, J ;
Wit, JM .
JOURNAL OF PEDIATRICS, 2005, 147 (06) :843-846
[8]  
FRISANCHO AR, 1970, HUM BIOL, V42, P639
[9]   Recovery from osteoporosis through skeletal growth: early bone mass acquisition has little effect on adult bone density [J].
Gafni, RI ;
McCarthy, EF ;
Hatcher, T ;
Meyers, JL ;
Inoue, N ;
Reddy, C ;
Weise, M ;
Barnes, KM ;
Abad, V ;
Baron, J .
FASEB JOURNAL, 2002, 16 (03) :736-+
[10]   Catch-up growth is associated with delayed senescence of the growth plate in rabbits [J].
Gafni, RI ;
Weise, M ;
Robrecht, DT ;
Meyers, JL ;
Barnes, KM ;
De-Levi, S ;
Baron, J .
PEDIATRIC RESEARCH, 2001, 50 (05) :618-623