SYNTHESIS, ANTIBACTERIAL ACTIVITY STUDY OF NEW 3-((5-METHOXY-1H- BENZO[d]IMIDAZOLE-2-YLTHIO)METHYL)-2-CHLOROQUINOLINE DERIVATIVES

被引：0

作者：

Pokalwar, Rajkumar U. ^{[1
]}

Survase, Avinash A. ^{[2
]}

Kadam, Avdhut D. ^{[2
]}

机构：

[1] Degloor Coll, Dept Chem, Nanded 431717, Maharashtra, India

[2] Rayat Inst Res & Dev, Satara 415001, Maharashtra, India

来源：

HETEROCYCLIC LETTERS | 2022年 / 12卷 / 03期

关键词：

2-chloroquinolin-3-carbaldehydes; 5-methoxy-1H-benz0[d]imidazole-2-thiol; antibacterial; 3-((5-methoxy-1H-benz0[d]imidazol-2-ylthio)methyl)-2-chloroquinoline; Spectroscopic; ANTIMICROBIAL ACTIVITY; QUINOLINE; OMEPRAZOLE; AGENTS; PHARMACOLOGY; DESIGN;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and convenient with high yielding method was developed for the synthesis of 3-((5-methoxy-1H-benz0[d]imidazol-2-ylthio)methyl)-2-chloroquinoline derivatives using 2-chloroquinolin-3-carbaldehydes and 5-methoxy-1H-benzo[d]imidazole-2-thiol. All the newly synthesized compounds were analyzed by spectroscopic data such as (HNMR)-H-1, IR, Mass. The newly prepared compounds were screened for antimicrobial activity against bacterial strains Staphylococcus aureas (NCIM-2654), Bacillus subtilis (NCIM-2635), Escherichia coli (NCIM-2832) and Pseudomonas aeruginosa (NCIM-5032). These newly synthesized materials exhibit good to moderate antimicrobial activity against one Gram positive and one Gram negative pathogenic strains.

引用

页码：587 / 596

页数：10

共 59 条

[1] 2-Chloroquinoline-3-carbaldehydes: synthesis, reactions and applications [J].

Abdel-Wahab, Bakr F. ;

Khidre, Rizk E. ;

Farahat, Abdelbasset A. ;

El-Ahl, Abdel-Aziz Sayed .

ARKIVOC, 2012, :211-276

[2] Elaborating on Efficient Anti-Proliferation Agents of Cancer Cells and Anti-Inflammatory-Based N-Bisphosphonic Acids [J].

Abdou, Wafaa M. ;

Khidre, Rizk E. ;

Kamel, Azza A. .

ARCHIV DER PHARMAZIE, 2012, 345 (02) :123-136

[3] Synthesis of Tetrazoloquinoline-Based Mono- and Bisphosphonate Esters as Potent Anti-Inflammatory Agents [J].

Abdou, Wafaa M. ;

Khidre, Rizk E. ;

Shaddy, Abeer A. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (01) :33-41

[4] Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells [J].

Adsule, Shreelekha ;

Barve, Vivek ;

Chen, Di ;

Ahmed, Fakhara ;

Dou, Q. Ping ;

Padhye, Subhash ;

Sarkar, Fazlul H. .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (24) :7242-7246

[5] Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols [J].

Ahmed, Nafees ;

Brahmbhatt, Keyur G. ;

Sabde, Sudeep ;

Mitra, Debashis ;

Singh, Inder Pal ;

Bhutani, Kamlesh K. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (08) :2872-2879

[6] Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives [J].

Ansari, K. F. ;

Lal, C. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) :4028-4033

[7] Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents [J].

Ansari, K. F. ;

Lal, C. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (05) :2294-2299

[8] POTENTIAL ANTITUMOR AGENTS .57. 2-PHENYLQUINOLINE-8-CARBOXAMIDES AS MINIMAL DNA-INTERCALATING ANTITUMOR AGENTS WITH INVIVO SOLID TUMOR-ACTIVITY [J].

ATWELL, GJ ;

BAGULEY, BC ;

DENNY, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :396-401

[9]

Bawa S, 2009, INDIAN J CHEM B, V48, P142

[10]

BHADURI AP, 1990, SYNLETT, P557

← 1 2 3 4 5 6 →