Targeting LRRK2 mutations in Parkinson's disease

被引：1
|
作者：
Lesniak, Robert K. [1 ,2 ]
Nichols, Robert Jeremy [2 ]
Smith, Mark [1 ]
Montine, Thomas J. [2 ]
机构：
[1] Stanford Univ, Sarafan ChEM H, Med Chem Knowledge Ctr, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Pathol, 300 Pasteur Dr, Stanford, CA 94305 USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2022年 / 14卷 / 16期
关键词：
computational chemistry and molecular modeling; drug design; drug discovery; inflammation therapeutics; neurological therapeutics; pharmacokinetics; pharmacodynamics; rare diseases; IDENTIFICATION; METAANALYSIS; DISCOVERY; DESIGN;
D O I：
10.4155/fmc-2022-0102
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：1167 / 1170
页数：4
相关论文
共 50 条
  • [41] LRRK2 mutations in patients with Parkinson's disease from Peru and Uruguay
    Mata, I. F.
    Cosentino, C.
    Torres, L.
    Malca, V.
    Maeti, P.
    Ortega, O.
    Raggio, V.
    Aljanati, R.
    Ramos, G.
    Avila, A.
    Dieguez, E.
    Zabetian, C. P.
    MOVEMENT DISORDERS, 2008, 23 (01) : S50 - S50
  • [42] LRRK2 and Parkinson's disease in Norway
    Toft, M.
    Haugarvoll, K.
    Ross, O. A.
    Farrer, M. J.
    Aasly, J. O.
    ACTA NEUROLOGICA SCANDINAVICA, 2007, 115 : 72 - 75
  • [43] Screening for LRRK2 mutations in UK familial Parkinson's disease patients
    Lewthwaite, A. J.
    Lambert, T. D.
    Wood, N. W.
    Nicholl, D. J.
    Morrison, K. E.
    MOVEMENT DISORDERS, 2007, 22 : S102 - S103
  • [44] Parkinson's disease LRRK2 gene mutations in the central region of Portugal
    Moreira, F.
    Morgadinho, A.
    Almeida, R.
    Goncalves, A.
    Januario, C.
    MOVEMENT DISORDERS, 2013, 28 : S411 - S411
  • [45] Lrrk2 mutations in south america: a study of Chilean Parkinson's disease
    Perez-Pastene, Carolina
    Cobb, Stephanie A.
    Diaz-Grez, Fernando
    Hulihan, Mary A.
    Miranda, Marcelo
    Venegas, Pablo
    Godoy, Osvaldo Trujillo
    Kachergus, Jennifer M.
    Ross, Owen A.
    Layson, Luis
    Farrer, Matthew J.
    Segura-Aguilar, Juan
    NEUROSCIENCE LETTERS, 2007, 422 (03) : 193 - 197
  • [46] Frequency of the LRRK2 and GBA mutations in Russian population with Parkinson's disease
    Senkevich, K.
    Emelyanov, A.
    Nikolaev, M.
    Usenko, T.
    Bezrukova, A.
    Miliukhina, I.
    Kopytova, A.
    Timofeeva, A.
    Yakimovsky, A.
    Pchelina, S.
    MOVEMENT DISORDERS, 2018, 33 : S632 - S632
  • [47] Screening LRRK2 gene mutations in patients with Parkinson's disease in Ghana
    Cilia, Roberto
    Sironi, Francesca
    Akpalu, Albert
    Cham, Momodou
    Sarfo, Fred Stephen
    Brambilla, Tiziana
    Bonetti, Alba
    Amboni, Marianna
    Goldwurm, Stefano
    Pezzoli, Gianni
    JOURNAL OF NEUROLOGY, 2012, 259 (03) : 569 - 570
  • [48] Screening LRRK2 gene mutations in patients with Parkinson’s disease in Ghana
    Roberto Cilia
    Francesca Sironi
    Albert Akpalu
    Momodou Cham
    Fred Stephen Sarfo
    Tiziana Brambilla
    Alba Bonetti
    Marianna Amboni
    Stefano Goldwurm
    Gianni Pezzoli
    Journal of Neurology, 2012, 259 : 569 - 570
  • [49] LRRK2 mutations and Parkinson's disease in Sardinia -: A Mediterranean genetic isolate
    Cossu, Giovanni
    van Doeselaar, Marina
    Deriu, Marcello
    Melis, Maurizio
    Molari, Andrea
    Di Fonzo, Alessio
    Oostra, Ben A.
    Bonifati, Vincenzo
    PARKINSONISM & RELATED DISORDERS, 2007, 13 (01) : 17 - 21
  • [50] LRRK2 mutations in a population-based study of Parkinson's disease
    Nelson, LM
    Langston, JW
    Tanner, CM
    Myers, RM
    Southwick, A
    Doostzadeh, J
    Topol, B
    Tabor, HK
    Farrar, MJ
    McGuire, V
    Popat, R
    Bernstein, A
    Leimpeter, AD
    Van den Eeden, SK
    MOVEMENT DISORDERS, 2005, 20 (09) : 1235 - 1236
12345