The pre-B cell receptor checkpoint

被引：51

作者：

Martensson, Inga-Lill ^{[1
]}

Almqvist, Nina ^{[1
]}

Grimsholm, Ola ^{[1
]}

Bernardi, Angelina I. ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Rheumatol & Inflammat Res, SE-40530 Gothenburg, Sweden

来源：

FEBS LETTERS | 2010年 / 584卷 / 12期

基金：

瑞典研究理事会;

关键词：

Antibody; B cell; Pre-B cell receptor checkpoint; Positive selection; Negative selection; SURROGATE LIGHT-CHAIN; MU-HEAVY-CHAIN; ALLELIC EXCLUSION; LYMPHOCYTE DEVELOPMENT; TARGETED DISRUPTION; V(D)J RECOMBINATION; DOWN-REGULATION; DEFICIENT MICE; MEMBRANE EXON; BONE-MARROW;

D O I：

10.1016/j.febslet.2010.04.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2572 / 2579

页数：8

共 51 条

[1] ORDERED REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SEGMENTS [J].

ALT, FW ;

YANCOPOULOS, GD ;

BLACKWELL, TK ;

WOOD, C ;

THOMAS, E ;

BOSS, M ;

COFFMAN, R ;

ROSENBERG, N ;

TONEGAWA, S ;

BALTIMORE, D .

EMBO JOURNAL, 1984, 3 (06) :1209-1219

[2] STRUCTURE AND PRE-B LYMPHOCYTE RESTRICTED EXPRESSION OF THE VPREB GENE IN HUMANS AND CONSERVATION OF ITS STRUCTURE IN OTHER MAMMALIAN-SPECIES [J].

BAUER, SR ;

KUDO, A ;

MELCHERS, F .

EMBO JOURNAL, 1988, 7 (01) :111-116

[3] Plugging the Leaky Pre-B Cell Receptor [J].

Conley, Mary Ellen ;

Burrows, Peter D. .

JOURNAL OF IMMUNOLOGY, 2010, 184 (03) :1127-1129

[4] Primary B Cell Immunodeficiencies: Comparisons and Contrasts [J].

Conley, Mary Ellen ;

Dobbs, A. Kerry ;

Farmer, Dana M. ;

Kilic, Sebnem ;

Paris, Kenneth ;

Grigoriadou, Sofia ;

Coustan-Smith, Elaine ;

Howard, Vanessa ;

Campana, Dario .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :199-227

[5]

DALY J, 2007, EMBO J

[6] The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion [J].

Flemming, A ;

Brummer, T ;

Reth, M ;

Jumaa, H .

NATURE IMMUNOLOGY, 2003, 4 (01) :38-43

[7] Surface μ heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components [J].

Galler, GR ;

Mundt, C ;

Parker, M ;

Pelanda, R ;

Mårtensson, IL ;

Winkler, TH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) :1523-1532

[8] DOWN-REGULATION OF RAG1 AND RAG2 GENE-EXPRESSION IN PREB CELLS AFTER FUNCTIONAL IMMUNOGLOBULIN HEAVY-CHAIN REARRANGEMENT [J].

GRAWUNDER, U ;

LEU, TMJ ;

SCHATZ, DG ;

WERNER, A ;

ROLINK, AG ;

MELCHERS, F ;

WINKLER, TH .

IMMUNITY, 1995, 3 (05) :601-608

[9] B cell development pathways [J].

Hardy, RR ;

Hayakawa, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :595-621

[10] IMMUNOGLOBULIN-LAMBDA LIGHT-CHAIN-RELATED GENES 14.1 AND 16.1 ARE EXPRESSED IN PRE-B CELLS AND MAY ENCODE THE HUMAN IMMUNOGLOBULIN-OMEGA LIGHT-CHAIN PROTEIN [J].

HOLLIS, GF ;

EVANS, RJ ;

STAFFORDHOLLIS, JM ;

KORSMEYER, SJ ;

MCKEARN, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5552-5556

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