Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

被引：8

作者：

Huh, Sung Woo ^{[1
]}

Shetty, Asode Ananthram ^{[2
]}

Kim, Jang Mook ^{[3
]}

Cho, Mi-La ^{[4
]}

Kim, Seon Ae ^{[1
]}

Yang, Siyoung ^{[5
]}

Kim, Young Ju ^{[6
]}

Javaregowda, Palaksha Kanive ^{[7
]}

Choi, Nam Yong ^{[1
]}

Kang, Jin ^{[1
]}

Kim, Seok Jung ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Orthopaed Surg, Seoul, South Korea

[2] Canterbury Christ Church Univ, Inst Med Sci, Fac Hlth & Wellbeing, Canterbury, Kent, England

[3] Dankook Univ, Coll Hlth Sci, Dept Hlth Adm, 119 Dandae Ro, Cheonan 31116, South Korea

[4] Catholic Univ Korea, Lab Immune Network, Rheumatism Res Ctr, Dept Life Sci,Coll Med, Seoul, South Korea

[5] Ajou Univ, Sch Med, Dept Pharmacol, Suwon 441749, South Korea

[6] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Nursing Educ & Adm, Uijongbu, South Korea

[7] SDM Coll Med Sci & Hosp, Dharwad, Karnataka, India

来源：

TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2016年 / 13卷 / 02期

关键词：

Osteoarthritis; Total knee arthroplasty; Chondrogenesis; Mesenchymal cell induced chondrogenesis; Economy; CARTILAGE REPAIR; MICROFRACTURE TECHNIQUE; REVISION SURGERY; 10-YEAR SURVIVAL; UNITED-STATES; ARTHROPLASTY; REPLACEMENT; HIP; INFILTRATION; EFFICACY;

D O I：

10.1007/s13770-016-9125-y

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients' satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.

引用

页码：200 / 209

页数：10

共 29 条

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