Hydro- and silylcyanation of cholic acid derivatives. Synthesis of novel pincer ligands based on litocholic acid

被引：1
作者：
Lukashev, N. V. [1 ]
Kazantsev, A. V. [1 ]
Beletskaya, I. P. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 50卷 / 10期
关键词：
BILE-ACIDS; MOLECULAR RECOGNITION; HYBRID MACROCYCLES; BINDING-PROPERTIES; LITHOCHOLIC ACID; RECEPTORS; CHOLAPHANES; NMR; CHEMISTRY; STEROIDS;
D O I：
10.1134/S1070428014100017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of 3-oxo derivatives of cholic acid esters with acetone cyanohydrin and trimethylsilyl cyanide lead to exclusive or predominant formation of the corresponding 3-cyano-3-hydroxy and 3-cyano-3-trimethylsiloxy derivatives with axial orientation of the cyano group. Reduction of the cyano group in the addition products gives 3-aminomethyl derivatives which can be used to obtain pincer ligands containing two cholane fragments.
引用
收藏
页码：1389 / 1396
页数：8
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