Hydrodynamic diameter and zeta potential of nanostructured lipid carriers: Emphasizing some parameters for correct measurements

被引：41

作者：

Gordillo-Galeano, Aldemar ^{[1
]}

Mora-Huertas, Claudia Elizabeth ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Carrera 30 45-03,Edificio 450, Bogota 111321, Colombia

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2021年 / 620卷

关键词：

Electric double-layer overlapping; Nanostructured lipid carriers; Ionogenic particles; Soft colloidal particles; DRUG-DELIVERY SYSTEM; ELECTROPHORETIC MOBILITY; SURFACE CONDUCTIVITY; PHYSICAL STABILITY; NANOPARTICLES SLN; DOUBLE-LAYER; POLYMER; LIGHT; ADSORPTION; TEMPERATURE;

D O I：

10.1016/j.colsurfa.2021.126610

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Particle size and zeta potential are basic information about nanoparticles intended for biomedical applications and other of scientific interest. Modern techniques for measuring these properties have become popular due to their simplicity and ease of use, but unfortunately, this has led to an inadequate understanding of the fundamental operational principles and physical meaning of the measured parameters. Consequently, the quality and interpretation of the reported data and the possibility to make comparisons between different studies are being questioned. As a contribution to this respect, this study stresses the importance of suitable experimental conditions to estimate the hydrodynamic diameter and the surface charge of lipid nanoparticles, specifically in nanostructured lipid carriers (NLC) stabilized by nonionic surfactants, by using dynamic light scattering and laser Doppler electrophoresis, respectively, to provide reliable information.

引用

页数：11

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