Synthesis of benzofuro- and benzothieno[2,3-c]pyridines via copper-catalyzed [4+2] annulation of ketoxime acetates with acetoacetanilide

被引：20

作者：

Rong, Binsen ^{[1
]}

Xu, Gaochen ^{[1
]}

Yan, Huan ^{[1
]}

Zhang, Sai ^{[1
]}

Wu, Qinghuan ^{[1
]}

Zhu, Ning ^{[1
]}

Fang, Zheng ^{[1
]}

Duan, Jindian ^{[1
]}

Guo, Kai ^{[1
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, 30 Puzhu Rd S, Nanjing 211816, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

CASCADE REACTION; ACYL OXIMES; METAL-FREE; RING; FLUORESCENT; KETONES; SERIES; DYE;

D O I：

10.1039/d1qo00094b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed annulation of ketoxime acetates with acetoacetanilide has been developed. This strategy provides an alternate route towards the synthesis of benzofuro- and benzothieno[2,3-c]pyridines with good functional group tolerance and operational simplicity. Mechanistic investigation indicates that an ionic pathway rather than a radical pathway was involved in the transformation.

引用

页码：2939 / 2943

页数：5

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