NF-κB and HIF crosstalk in immune responses

被引:293
作者
D'Ignazio, Laura [1 ]
Bandarra, Daniel [1 ]
Rocha, Sonia [1 ]
机构
[1] Univ Dundee, Coll Life Sci, Ctr Gene Regulat & Express, Dundee, Scotland
关键词
B cells; HIF; hypoxia; IKK; immune response; inflammation; macrophages; neutrophils; NF-kappa B; T cells; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; INNATE IMMUNITY; SIGNALING PATHWAY; CELL-DEVELOPMENT; GENE-EXPRESSION; FACTOR; 2-ALPHA; FACTOR-I; T-CELLS; ACTIVATION; MACROPHAGES;
D O I
10.1111/febs.13578
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hypoxia and inflammation have been associated with a number of pathological conditions, in particular inflammatory diseases. While hypoxia is mainly associated with the activation of hypoxia-inducible factors (HIFs), inflammation activates the family of transcription factor called nuclear factor-kappa B (NF-B). An extensive crosstalk between these two main molecular players involved in hypoxia and inflammation has been demonstrated. This crosstalk includes common activating stimuli, shared regulators and targets. In this review, we discuss the current understanding of the role of NF-B and HIF in the context of the immune response. We review the crosstalk between HIF and NF-B in the control of the immune response in different immune cell types including macrophages, neutrophils and B and T cells. Furthermore the importance of the molecular crosstalk between HIFs and NF-B for a variety of medical conditions will be discussed.
引用
收藏
页码:413 / 424
页数:12
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