System-level design of bacterial cell cycle control

被引:38
作者
McAdams, Harley H. [1 ]
Shapiro, Lucy [1 ]
机构
[1] Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA
关键词
Cell cycle; Cell regulation; Systems biology; Robustness; Cell biology; Caulobacter; CAULOBACTER-CRESCENTUS; DNA METHYLTRANSFERASE; PROTEASE COMPLEX; GENETIC CIRCUIT; REPLICATION; PROGRESSION; DIVISION; PROTEOBACTERIA; TRANSCRIPTION; ARCHITECTURE;
D O I
10.1016/j.febslet.2009.09.030
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Understanding of the cell cycle control logic in Caulobacter has progressed to the point where we now have an integrated view of the operation of an entire bacterial cell cycle system functioning as a state machine. Oscillating levels of a few temporally-controlled master regulator proteins in a cyclical circuit drive cell cycle progression. To a striking degree, the cell cycle regulation is a whole cell phenomenon. Phospho-signaling proteins and proteases dynamically deployed to specific locations on the cell wall are vital. An essential phospho-signaling system integral to the cell cycle circuitry is central to accomplishing asymmetric cell division. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:3984 / 3991
页数:8
相关论文
共 32 条
  • [11] Molecules into cells: Specifying spatial architecture
    Harold, FM
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2005, 69 (04) : 544 - 564
  • [12] Oscillating global regulators control the genetic circuit driving a bacterial cell cycle
    Holtzendorff, J
    Hung, D
    Brende, P
    Reisenauer, A
    Viollier, PH
    McAdams, HH
    Shapiro, L
    [J]. SCIENCE, 2004, 304 (5673) : 983 - 987
  • [13] DnaA coordinates replication initiation and cell cycle transcription in Caulobacter crescentus
    Hottes, AK
    Shapiro, L
    McAdams, HH
    [J]. MOLECULAR MICROBIOLOGY, 2005, 58 (05) : 1340 - 1353
  • [14] Bacterial birth scar proteins mark future flagellum assembly site
    Huitema, E
    Pritchard, S
    Matteson, D
    Radhakrishnan, SK
    Viollier, PH
    [J]. CELL, 2006, 124 (05) : 1025 - 1037
  • [15] A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression
    Iniesta, Antonio A.
    McGrath, Patrick T.
    Reisenauer, Ann
    McAdams, Harley H.
    Shapiro, Lucy
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (29) : 10935 - 10940
  • [16] Distinct constrictive processes, separated in time and space, divide Caulobacter inner and outer membranes
    Judd, EM
    Comolli, LR
    Chen, JC
    Downing, KH
    Moerner, WE
    McAdams, HH
    [J]. JOURNAL OF BACTERIOLOGY, 2005, 187 (20) : 6874 - 6882
  • [17] Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter
    Judd, EM
    Ryan, KR
    Moerner, WE
    Shapiro, L
    McAdams, HH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) : 8235 - 8240
  • [18] A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell
    Lam, H
    Schofield, WB
    Jacobs-Wagner, C
    [J]. CELL, 2006, 124 (05) : 1011 - 1023
  • [19] Cytokinesis monitoring during development:: Rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter
    Matroule, JY
    Lam, H
    Burnette, DT
    Jacobs-Wagner, C
    [J]. CELL, 2004, 118 (05) : 579 - 590
  • [20] A bacterial cell-cycle regulatory network operating in time and space
    McAdams, HH
    Shapiro, L
    [J]. SCIENCE, 2003, 301 (5641) : 1874 - 1877