SARS-CoV-2 outbreak in a nursing home after vaccination with BNT162b2: A role for the quantification of circulating antibodies

被引：3

作者：

Camara, Jordi ^{[1
,2
]}

Gonzalez-Diaz, Aida ^{[1
,2
]}

Barrabeig, Irene ^{[3
,4
]}

Fernandez-Huerta, Miguel ^{[1
]}

Calatayud, Laura ^{[1
,2
]}

Niubo, Jordi ^{[1
]}

Marti, Sara ^{[1
,2
]}

Angeles Dominguez, Ma ^{[1
,5
,6
]}

Ardanuy, Carmen ^{[1
,2
,6
]}

机构：

[1] Univ Barcelona, Hosp Univ Bellvitge, IDIBELL, Microbiol Dept, C Feixa Llarga S-N, Lhospitalet De Llobregat 08907, Spain

[2] ISCIII, CIBER Enfermedades Resp CIBERes, Madrid, Spain

[3] Generalitat Catalonia, Agcy Publ Hlth Catalonia, Epidemiol Surveillance & Response Publ Hlth Emerg, Barcelona, Spain

[4] ISCIII, CIBER Epidemiol & Salud Publ CIBEResp, Madrid, Spain

[5] ISCIII, CIBER Enfermedades Infecciosas CIBERinfec, Madrid, Spain

[6] Univ Barcelona, Dept Pathol & Expt Therapeut, Barcelona, Spain

来源：

VACCINE | 2022年 / 40卷 / 18期

关键词：

SARS-CoV-2; COVID-19; Outbreak; Vaccine; B.1.351;

D O I：

10.1016/j.vaccine.2022.03.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe an outbreak of SARS-CoV-2 (B.1.351) in a nursing home. At the outbreak onset 96% of residents and 76% of HCW had received two doses of BNT162b2. Twenty-eight residents (28/53) and six HCW (6/33) were infected. Infected residents had lower levels of anti-S antibodies compared to those who were not infected (157 vs 552 U/mL). Among 50 residents with available serological status, nineteen (19/25) with serum concentration < 300 U/mL and seven (7/25) with concentration > 300 U/mL acquired SARS-CoV-2 (RR 2.7 [95 %CI 1.4-5.3]). The quantification of circulating antibodies could be useful in detecting people with an impaired immune response who are at high risk of acquiring and spreading SARS-CoV-2. (c) 2022 Elsevier Ltd. All rights reserved.

引用

页码：2531 / 2534

页数：4

共 13 条

[1] BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity
Bailly, Benoit
Guilpain, Luc
Bouiller, Kevin
Chirouze, Catherine
N'Debi, Melissa
Soulier, Alexandre
Demontant, Vanessa
Pawlotsky, Jean-Michel
Rodriguez, Christophe
Fourati, Slim
[J]. CLINICAL INFECTIOUS DISEASES, 2022, 74 (03) : 517 - 520
[2] Immune response to SARS-CoV-2 variants of concern in vaccinated individuals
Becker, Matthias
Dulovic, Alex
Junker, Daniel
Ruetalo, Natalia
Kaiser, Philipp D.
Pinilla, Yudi T.
Heinzel, Constanze
Haering, Julia
Traenkle, Bjoern
Wagner, Teresa R.
Layer, Mirjam
Mehrlaender, Martin
Mirakaj, Valbona
Held, Jana
Planatscher, Hannes
Schenke-Layland, Katja
Krause, Gerard
Strengert, Monika
Bakchoul, Tamam
Althaus, Karina
Fendel, Rolf
Kreidenweiss, Andrea
Koeppen, Michael
Rothbauer, Ulrich
Schindler, Michael
Schneiderhan-Marra, Nicole
[J]. NATURE COMMUNICATIONS, 2021, 12 (01)
[3] Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents
Canaday, David H.
Carias, Lenore
Oyebanji, Oladayo A.
Keresztesy, Debbie
Wilk, Dennis
Payne, Michael
Aung, Htin
St Denis, Kerri
Lam, Evan C.
Rowley, Christopher F.
Berry, Sarah D.
Cameron, Cheryl M.
Cameron, Mark J.
Wilson, Brigid
Balazs, Alejandro B.
Gravenstein, Stefan
King, Christopher L.
[J]. CLINICAL INFECTIOUS DISEASES, 2021, 73 (11) : 2112 - 2115
[4] Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma
Cele, Sandile
Gazy, Inbal
Jackson, Laurelle
Hwa, Shi-Hsia
Tegally, Houriiyah
Lustig, Gila
Giandhari, Jennifer
Pillay, Sureshnee
Wilkinson, Eduan
Naidoo, Yeshnee
Karim, Farina
Ganga, Yashica
Khan, Khadija
Bernstein, Mallory
Balazs, Alejandro B.
Gosnell, Bernadett, I
Hanekom, Willem
Moosa, Mahomed-Yunus S.
Lessells, Richard J.
de Oliveira, Tulio
Sigal, Alex
[J]. NATURE, 2021, 593 (7857) : 142 - +
[5] Gaebler C, 2021, NATURE, V591, P639, DOI [10.1038/s41586-021-03207-w, 10.1101/2020.11.03.367391]
[6] Garcia-Beltran WF, 2021, CELL, V184, P2372, DOI [10.1016/j.cell.2021.03.013, 10.1101/2021.02.14.21251704, 10.1016/j.cell.2021.04.006]
[7] SARS-CoV-2 variants of concern partially escape humoral but not T- cell responses in COVID-19 convalescent donors and vaccinees
Geers, Daryl
Shamier, Marc C.
Bogers, Susanne
den Hartog, Gerco
Gommers, Lennert
Nieuwkoop, Nella N.
Schmitz, Katharina S.
Rijsbergen, Laurine C.
van Osch, Jolieke A. T.
Dijkhuizen, Emma
Smits, Gaby
Comvalius, Anouskha
van Mourik, Djenolan
Caniels, Tom G.
van Gils, Marit J.
Sanders, Rogier W.
Munnink, Bas B. Oude
Molenkamp, Richard
de Jager, Herbert J.
Haagmans, Bart L.
de Swart, Rik L.
Koopmans, Marion P. G.
van Binnendijk, Robert S.
de Vries, Rory D.
GeurtsvanKessel, Corine H.
[J]. SCIENCE IMMUNOLOGY, 2021, 6 (59)
[8] RAxML-NG: a fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference
Kozlov, Alexey M.
Darriba, Diego
Flouri, Tomas
Morel, Benoit
Stamatakis, Alexandros
[J]. BIOINFORMATICS, 2019, 35 (21) : 4453 - 4455
[9] Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
Long, Quan-Xin
Tang, Xiao-Jun
Shi, Qiu-Lin
Li, Qin
Deng, Hai-Jun
Yuan, Jun
Hu, Jie-Li
Xu, Wei
Zhang, Yong
Lv, Fa-Jin
Su, Kun
Zhang, Fan
Gong, Jiang
Wu, Bo
Liu, Xia-Mao
Li, Jin-Jing
Qiu, Jing-Fu
Chen, Juan
Huang, Ai-Long
[J]. NATURE MEDICINE, 2020, 26 (08) : 1200 - +
[10] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, Fernando P.
Thomas, Stephen J.
Kitchin, Nicholas
Absalon, Judith
Gurtman, Alejandra
Lockhart, Stephen
Perez, John L.
Perez Marc, Gonzalo
Moreira, Edson D.
Zerbini, Cristiano
Bailey, Ruth
Swanson, Kena A.
Roychoudhury, Satrajit
Koury, Kenneth
Li, Ping
Kalina, Warren V.
Cooper, David
Frenck, Robert W., Jr.
Hammitt, Laura L.
Tureci, Ozlem
Nell, Haylene
Schaefer, Axel
Unal, Serhat
Tresnan, Dina B.
Mather, Susan
Dormitzer, Philip R.
Sahin, Ugur
Jansen, Kathrin U.
Gruber, William C.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) : 2603 - 2615

← 1 2 →