Transplantation of human immature dental pulp stem cell in dogs with chronic spinal cord injury

被引：20

作者：

Tajra Feitosa, Matheus Levi ^{[1
,8
,9
]}

Palmeira Sarmento, Carlos Alberto ^{[1
,8
,9
]}

Bocabello, Renato Zonzini ^{[2
,8
,9
]}

Baleeiro Beltrao-Braga, Patricia Cristina ^{[2
,8
,9
]}

Pignatari, Graciela Conceicao ^{[3
,8
,9
]}

Giglio, Robson Fortes ^{[4
,8
,9
]}

Miglino, Maria Angelica ^{[5
,6
,8
,9
]}

Orlandin, Jessica Rodrigues ^{[7
,8
,9
]}

Ambrosio, Carlos Eduardo ^{[5
,7
,8
,9
]}

机构：

[1] Univ Sao Paulo, Dept Surg, Fac Vet Med & Anim Sci, Postgrad Program Anat Domest & Wild Anim, Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Dept Surg, Stem Cell Lab, Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Dept Surg, Fac Vet Med & Anim Sci, Sao Paulo, SP, Brazil

[4] Univ Florida, Coll Vet Med, Dept Clin Sci, Gainesville, FL USA

[5] CNPq Grant Level 1A CA VT, Pirassunung, SP, Brazil

[6] Univ Sao Paulo, Dept Vet Med, Fac Anim Sci & Food Engn, Pirassunung, SP, Brazil

[7] Univ Sao Paulo, Postgrad Program Anim Biosci, Lab Stem Cell & Gene Therapy, Vet Med Dept,Fac Anim Sci & Food Engn, Pirassunung, SP, Brazil

[8] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Surg, Stem Cell Lab, Pirassununga, SP, Brazil

[9] Univ Sao Paulo, Lab Stem Cell & Gene Therapy, Vet Med Dept, Fac Anim Sci & Food Engn, Pirassununga, SP, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2017年 / 32卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

Cell- and Tissue-Based Therapy; Spinal Cord Injuries; Dental Pulp; Dogs; PROMOTES FUNCTIONAL RECOVERY; MARROW STROMAL CELLS; HUMAN BONE-MARROW;

D O I：

10.1590/s0102-865020170070000005

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.

引用

页码：540 / 549

页数：10

共 30 条

[1] Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].