Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain

被引:15
|
作者
Foucault, Gonzague [1 ,2 ]
Duval, Guillaume T. [1 ,2 ]
Simon, Romain [1 ]
Beauchet, Olivier [5 ,6 ]
Dinomais, Mickael [2 ,3 ,4 ]
Annweiler, Cedric [1 ,2 ,7 ]
机构
[1] Univ Angers, Angers Univ Hosp, Dept Geriatr Med, Memory Clin,Res Ctr Auton & Longev,UPRES EA 4638, Angers, France
[2] Univ Angers, Hlth Fac, Sch Med, Angers, France
[3] Univ Angers, LARIS EA7315, F-49000 Angers, France
[4] Univ Angers, Dept Med Phys & Readaptat, CHU Angers, F-49933 Angers, France
[5] McGill Univ, Dept Med, Div Geriatr Med, Sir Mortimer B Davis Jewish Gen Hosp, Montreal, PQ, Canada
[6] McGill Univ, Lady Davis Inst Med Res, Montreal, PQ, Canada
[7] Univ Western Ontario, Dept Med Biophys, Robarts Res Inst, Schulich Sch Med & Dent, London, ON, Canada
关键词
Brain; cingulate cortex; magnetic resonance imaging; older adults; vitamin D; memory disorders; 25-HYDROXYVITAMIN D CONCENTRATIONS; MILD COGNITIVE IMPAIRMENT; NERVE GROWTH-FACTOR; GRAY-MATTER VOLUME; ALZHEIMERS-DISEASE; AMYLOID-BETA; WHITE-MATTER; 1,25-DIHYDROXYVITAMIN D-3; SCHIZOPHRENIA; SEGMENTATION;
D O I
10.2174/1567205016666191113124356
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Objective: Our objective was to investigate in older adults whether vitamin D insufficiency<50nmol/L was associated with thinner cingulate cortex, a brain area related to cognitive functions influenced by vitamin D. Methods: Two hundred and fifteen Caucasian older community-dwellers (mean +/- ESD, 72.1 +/- 5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6 +/- 1.9mm versus 25.3 +/- 1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (beta=-0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.
引用
收藏
页码:1063 / 1071
页数:9
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