Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanatnivir)

被引：18
作者：
Liu, Zong-ying
Wang, Bo
Zhao, Li-xun
Li, Yu-huan
Shao, Hua-yi
Yi, Hong
You, Xue-fu
Li, Zhuo-rong [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 17期
关键词：
alkoxyalkyl ester; influenza; zanamivir;
D O I：
10.1016/j.bmcl.2007.06.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three alkoxyalkyl 2-carboxylate ester derivatives related to zanamivir were synthesized. All of the analogs of zanamivir modified at carboxylic moiety with alkoxyalkyl esters 1a-c showed higher activities than ribavirin on influenza A and B virus in the MDCK cells. Oral treatment or intraperitoneal administration of compound le showed significantly protective effects in mice infected with influenza A virus with low toxicities. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4851 / 4854
页数：4
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