Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae

被引：21
作者：
Awakawa, Takayoshi [1 ,2 ]
Abe, Ikuro [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Nat Prod Chem, Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Collaborat Res Inst Innovat Microbiol, Bunkyo Ku, Yayoi 1-1-1, Tokyo 1138657, Japan
来源：
JOURNAL OF FUNGI | 2021年 / 7卷 / 06期
关键词：
Aspergillus oryzae; heterologous expression; secondary metabolites; meroterpenoid; TERRETONIN BIOSYNTHESIS; TRANSFORMATION SYSTEM; GENE; IDENTIFICATION; CLONING; HOST; CONSTRUCTION; DISRUPTION; EXPRESSION; DISCOVERY;
D O I：
10.3390/jof7060486
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide-derived meroterpenoids, a group of bioactive natural products, by means of the A. oryzae heterologous expression system. The heterologous expression methods and the biosynthetic reactions are described in detail for future prospects to create un-natural molecules via biosynthetic re-design.
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页数：10
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