Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment

被引：396

作者：

Liu, Jingjing ^{[1
]}

Yang, Yu ^{[2
]}

Zhu, Wenwen ^{[1
]}

Yi, Xuan ^{[3
]}

Dong, Ziliang ^{[1
]}

Xu, Xiaona ^{[1
]}

Chen, Meiwan ^{[2
]}

Yang, Kai ^{[3
,4
]}

Lu, Guang ^{[1
]}

Jiang, Lixin ^{[5
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[2] Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Ave Univ, Taipa, Macau, Peoples R China

[3] Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China

[4] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Jiangsu Prov Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China

[5] Shanghai Jiao Tong Univ, Dept Ultrasound Med, Yishan Rd 600, Shanghai 200233, Peoples R China

来源：

BIOMATERIALS | 2016年 / 97卷

基金：

中国国家自然科学基金;

关键词：

Nanoscale metal-organic framework; Photodynamic therapy; Radiation therapy; Combination therapy; COORDINATION POLYMERS; RESISTANT HEAD; NANOPARTICLES; NANOMATERIALS;

D O I：

10.1016/j.biomaterials.2016.04.034

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf4+) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf4+ with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1 / 9

页数：9

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