MicroRNA-dependent genetic networks during neural development

被引：20

作者：

Abernathy, Daniel G. ^{[1
,2
]}

Yoo, Andrew S. ^{[1
]}

机构：

[1] Washington Univ, Dept Dev Biol, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Program Dev Regenerat & Stem Cell Biol, Sch Med, St Louis, MO 63110 USA

来源：

CELL AND TISSUE RESEARCH | 2015年 / 359卷 / 01期

关键词：

MicroRNAs; Neural development; Brain; Genetic networks; Direct reprogramming; Epigenetics; NUCLEAR RECEPTOR TLX; CENTRAL-NERVOUS-SYSTEM; CHROMATIN-REMODELING COMPLEXES; RESTRICTIVE SILENCER FACTOR; STEM-CELL PROLIFERATION; MESSENGER-RNAS; NEURONAL DIFFERENTIATION; TARGET RECOGNITION; INTERACTION SITES; REGULATORY LOOP;

D O I：

10.1007/s00441-014-1899-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of the structurally and functionally diverse mammalian nervous system requires the integration of numerous levels of gene regulation. Accumulating evidence suggests that microRNAs are key mediators of genetic networks during neural development. Importantly, microRNAs are found to regulate both feedback and feedforward loops during neural development leading to large changes in gene expression. These repressive interactions provide an additional mechanism that facilitates the establishment of complexity within the nervous system. Here, we review studies that have enabled the identification of microRNAs enriched in the brain and discuss the way that genetic networks in neural development depend on microRNAs.

引用

页码：179 / 185

页数：7

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