Biocatalysts from alkaloid producing plants

被引：28

作者：

Kries, Hajo ^{[1
]}

O'Connor, Sarah E. ^{[1
]}

机构：

[1] John Innes Ctr Plant Sci Res, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2016年 / 31卷

基金：

欧洲研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

PICTET-SPENGLER REACTION; CATHARANTHUS-ROSEUS; OPIUM POPPY; IRIDOID BIOSYNTHESIS; NOSCAPINE BIOSYNTHESIS; SYNTHETIC BIOLOGY; ENZYME; STEP; SYNTHASE; TETRAHYDROISOQUINOLINES;

D O I：

10.1016/j.cbpa.2015.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic pathways leading to benzylisoquinoline and monoterpene indole alkaloids in plants are revealing remarkable new reactions. Understanding of the enzymes involved in alkaloid biosynthesis provides access to a variety of applications in biocatalysis and bioengineering. In chemo-enzymatic settings, plant biocatalysts can transform medically important scaffolds. Additionally, synthetic biologists are taking alkaloid pathways as templates to assemble pathways in microorganisms that are tailored to the needs of medicinal chemistry. In light of these many recent discoveries, it is expected that plants will continue to be a source of novel biocatalysts for the foreseeable future.

引用

页码：22 / 30

页数：9

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