Neutrophils in COVID-19: Not Innocent Bystanders

被引:64
|
作者
McKenna, Ellen [1 ,2 ]
Wubben, Richard [3 ]
Isaza-Correa, Johana M. [1 ,2 ]
Melo, Ashanty M. [1 ,2 ]
Mhaonaigh, Aisling Ui [4 ]
Conlon, Niall [5 ]
O'Donnell, James S. [6 ]
Ni Cheallaigh, Cliona [7 ,8 ]
Hurley, Tim [1 ,2 ,9 ,10 ]
Stevenson, Nigel J. [3 ,11 ]
Little, Mark A. [4 ,6 ]
Molloy, Eleanor J. [1 ,2 ,9 ,10 ,12 ,13 ]
机构
[1] Univ Dublin, Dublin Trinity Coll, Discipline Paediat, Dublin, Ireland
[2] St James Hosp, Trinity Translat Med Inst TTMI, Paediat Res Lab, Dublin, Ireland
[3] Trinity Biomed Sci Inst, Sch Biochem & Immunol, Viral Immunol Grp, Dublin, Ireland
[4] Trinity Coll Dublin, Trinity Translat Med Inst TTMI, Trinity Hlth Kidney Ctr, Dublin, Ireland
[5] Trinity Coll Dublin, St James Hosp, Dept Immunol, Dublin, Ireland
[6] Irish Ctr Vasc Biol, Dublin, Ireland
[7] Trinity Coll Dublin, Trinity Ctr Hlth Sci, Dept Clin Med, Dublin, Ireland
[8] St James Hosp, Dept Infect Dis, Dublin, Ireland
[9] Coombe Women & Infants Univ Hosp, Neonatol, Dublin, Ireland
[10] Childrens Hosp Ireland CHI Crumlin, Natl Childrens Res Ctr, Dublin, Ireland
[11] Royal Coll Surg Ireland, Med Coll Bahrain, Viral Immunol Grp, Al Muharraq, Bahrain
[12] Childrens Hosp Ireland CHI Crumlin, Neonatol, Dublin, Ireland
[13] Tallaght Univ Hosp, Childrens Hosp Ireland CHI Tallaght, Paediat, Dublin, Ireland
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词
neutrophil; COVID-19; SARS-CoV-2; innate immunity; inflammation; MULTISYSTEM INFLAMMATORY SYNDROME; EXTRACELLULAR TRAPS; DISEASE; TOCILIZUMAB; MORTALITY; SEVERITY;
D O I
10.3389/fimmu.2022.864387
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Unusually for a viral infection, the immunological phenotype of severe COVID-19 is characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil-to-lymphocyte ratio correlating with disease severity. Neutrophils are the most abundant immune cell in the bloodstream and comprise different subpopulations with pleiotropic actions that are vital for host immunity. Unique neutrophil subpopulations vary in their capacity to mount antimicrobial responses, including NETosis (the generation of neutrophil extracellular traps), degranulation and de novo production of cytokines and chemokines. These processes play a role in antiviral immunity, but may also contribute to the local and systemic tissue damage seen in acute SARS-CoV-2 infection. Neutrophils also contribute to complications of COVID-19 such as thrombosis, acute respiratory distress syndrome and multisystem inflammatory disease in children. In this Progress review, we discuss the anti-viral and pathological roles of neutrophils in SARS-CoV-2 infection, and potential therapeutic strategies for COVID-19 that target neutrophil-mediated inflammatory responses.
引用
收藏
页数:12
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