New multispectral MRI data fusion technique for white matter lesion segmentation: method and comparison with thresholding in FLAIR images

被引:122
作者
Valdes Hernandez, Maria del C. [1 ,2 ,3 ]
Ferguson, Karen J. [2 ]
Chappell, Francesca M. [2 ]
Wardlaw, Joanna M. [2 ,3 ]
机构
[1] Univ Edinburgh, Western Gen Hosp, Div Clin Neurosci, SFC Brain Imaging Res Ctr,Image Anal Lab, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Univ Edinburgh, Sch Mol & Clin Med, Div Clin Neurosci, SFC Brain Imaging Res Ctr,SINAPSE Collaborat, Edinburgh EH4 2XU, Midlothian, Scotland
[3] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH4 2XU, Midlothian, Scotland
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词
White matter lesions; Leukoaraiosis; Ageing; Tissue segmentation; MRI; Multispectral segmentation; Threshold segmentation; FLAIR; HEALTHY ELDERLY MEN; MULTIPLE-SCLEROSIS; BRAIN MRI; HYPERINTENSITIES; QUANTIFICATION; ALGORITHM; IMPACT; VOLUME; MODEL; FIELD;
D O I
10.1007/s00330-010-1718-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Brain tissue segmentation by conventional threshold-based techniques may have limited accuracy and repeatability in older subjects. We present a new multispectral magnetic resonance (MR) image analysis approach for segmenting normal and abnormal brain tissue, including white matter lesions (WMLs). We modulated two 1.5T MR sequences in the red/green colour space and calculated the tissue volumes using minimum variance quantisation. We tested it on 14 subjects, mean age 73.3 +/- 10 years, representing the full range of WMLs and atrophy. We compared the results of WML segmentation with those using FLAIR-derived thresholds, examined the effect of sampling location, WML amount and field inhomogeneities, and tested observer reliability and accuracy. FLAIR-derived thresholds were significantly affected by the location used to derive the threshold (P = 0.0004) and by WML volume (P = 0.0003), and had higher intra-rater variability than the multispectral technique (mean difference +/- SD: 759 +/- 733 versus 69 +/- 326 voxels respectively). The multispectral technique misclassified 16 times fewer WMLs. Initial testing suggests that the multispectral technique is highly reproducible and accurate with the potential to be applied to routinely collected clinical MRI data.
引用
收藏
页码:1684 / 1691
页数:8
相关论文
共 30 条
[1]   Fully automatic segmentation of white matter hyperintensities in MR images of the elderly [J].
Admiraal-Behloul, F ;
van den Heuvel, DMJ ;
Olofsen, H ;
van Osch, MJP ;
van der Grond, J ;
van Buchem, MA ;
Relber, JHC .
NEUROIMAGE, 2005, 28 (03) :607-617
[2]   Probabilistic segmentation of brain tissue in MR imaging [J].
Anbeek, P ;
Vincken, KL ;
van Bochove, GS ;
van Osch, MJP ;
van der Grond, J .
NEUROIMAGE, 2005, 27 (04) :795-804
[3]   A dual approach for minimizing false lesion classifications on magnetic resonance images [J].
Bedell, BJ ;
Narayana, PA ;
Wolinsky, JS .
MAGNETIC RESONANCE IN MEDICINE, 1997, 37 (01) :94-102
[4]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[5]   The Lothian Birth Cohort 1936: A study to examine influences on cognitive ageing from age 11 to age 70 and beyond [J].
Deary I.J. ;
Gow A.J. ;
Taylor M.D. ;
Corley J. ;
Brett C. ;
Wilson V. ;
Campbell H. ;
Whalley L.J. ;
Visscher P.M. ;
Porteous D.J. ;
Starr J.M. .
BMC Geriatrics, 7 (1)
[6]   CT and MRI rating of white matter lesions [J].
Fazekas, F ;
Barkhof, F ;
Wahlund, LO ;
Pantoni, L ;
Erkinjuntti, T ;
Scheltens, P ;
Schmidt, R .
CEREBROVASCULAR DISEASES, 2002, 13 :31-36
[7]   Magnetic resonance spectroscopy and cognitive function in healthy elderly men [J].
Ferguson, KJ ;
MacLullich, AMJ ;
Marshall, I ;
Deary, IJ ;
Starr, JM ;
Seckl, JR ;
Wardlaw, JM .
BRAIN, 2002, 125 :2743-2749
[8]  
FLOYD RW, 1976, P SID, V17, P75
[9]  
Foley J.D., 1996, Computer graphics: Principles and practice
[10]   Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging [J].
Gootjes, L ;
Teipel, SJ ;
Zebuhr, Y ;
Schwarz, R ;
Leinsinger, G ;
Scheltens, P ;
Möller, HJ ;
Hampel, H .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2004, 18 (02) :180-188