Increased cerebellar vermis white-matter volume in men with schizophrenia

被引：32

作者：

Lee, Kwang-Hyuk

Farrow, Tom F. D.

Parks, Randolph W.

Newton, Lisa D.

Mir, Nusrat U.

Egleston, Paul N.

Brown, Wendy H.

Wilkinson, Iain D.

Woodruff, Peter W. R.

机构：

[1] Univ Sheffield, Sheffield Cognit & Neuroimaging Lab, Longley Ctr, Sheffield S5 7JT, S Yorkshire, England

[2] Univ Sheffield, Acad Unit Radiol, Sheffield, S Yorkshire, England

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2007年 / 41卷 / 08期

关键词：

schizophrenia; cerebellum; vermis; VBM; MRI; verbal fluency; COGNITIVE-AFFECTIVE SYNDROME; NEUROLEPTIC-NAIVE SCHIZOPHRENIA; CHILDHOOD-ONSET SCHIZOPHRENIA; 1ST-EPISODE SCHIZOPHRENIA; MOTOR CORTEX; MRI; DYSMETRIA; BRAIN; MORPHOMETRY; MORPHOLOGY;

D O I：

10.1016/j.jpsychires.2006.03.001

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We aimed to investigate cerebellar structural abnormalities and their functional significance in patients with schizophrenia. Forty right-handed men with schizophrenia and 40 sex, age and handedness matched controls underwent a volumetric magnetic resonance scan with 1 mm(3) isotropic spatial resolution. Cerebellar grey- and white-matter volumes were analysed using voxel-based morphometry. Patients with schizophrenia completed a battery of neuropsychological tests assessing sustained attention (continuous performance test), memory (Hopkins memory test) and executive function (verbal fluency and Wisconsin card sorting tests). Patients with schizophrenia exhibited significantly increased cerebellar vermis white-matter volume compared with controls. By contrast, total cerebellar volume, and grey- and white-matter volumes of cerebellar hemispheres were not significantly different between groups. Increased vermis white-matter volume in patients was associated with poor verbal fluency performance. We concluded that increased white-matter in the cerebellar vermis, possibly suggesting anomalous connectivity, may be associated with verbal executive dysfunction in men with chronic schizophrenia. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：645 / 651

页数：7

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