Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus)

被引：0
|
作者：
Phillips, Kimberley A. [1 ,2 ]
Lopez, Matthew [1 ,2 ]
Salmon, Adam B. [3 ,4 ]
Ross, Corinna N. [2 ]
Abbott, David H. [5 ]
Capitanio, John P. [6 ,7 ]
机构：
[1] Trinity Univ, Dept Psychol, San Antonio, TX 78212 USA
[2] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX USA
[3] Univ Texas Hlth San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, Dept Mol Med, San Antonio, TX USA
[4] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA
[5] Univ Wisconsin Madison, Dept Obstet & Gynecol, Wisconsin Natl Primate Res Ctr, Madison, WI USA
[6] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[7] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 2022年 / 51卷 / 06期
基金：
美国国家卫生研究院;
关键词：
common marmoset; dexamethasone suppression test; glucocorticoid; NONHUMAN-PRIMATES; ZONA-RETICULARIS; STRESS; ENDOCRINE; MONKEYS; IMPACT; MODEL; ACTH; AGE;
D O I：
10.1111/jmp.12602
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We conducted a dose-response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.
引用
收藏
页码：407 / 410
页数：4
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