Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus)

被引：0

作者：

Phillips, Kimberley A. ^{[1
,2
]}

Lopez, Matthew ^{[1
,2
]}

Salmon, Adam B. ^{[3
,4
]}

Ross, Corinna N. ^{[2
]}

Abbott, David H. ^{[5
]}

Capitanio, John P. ^{[6
,7
]}

机构：

[1] Trinity Univ, Dept Psychol, San Antonio, TX 78212 USA

[2] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX USA

[3] Univ Texas Hlth San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, Dept Mol Med, San Antonio, TX USA

[4] South Texas Vet Hlth Care Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX USA

[5] Univ Wisconsin Madison, Dept Obstet & Gynecol, Wisconsin Natl Primate Res Ctr, Madison, WI USA

[6] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

[7] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2022年 / 51卷 / 06期

基金：

美国国家卫生研究院;

关键词：

common marmoset; dexamethasone suppression test; glucocorticoid; NONHUMAN-PRIMATES; ZONA-RETICULARIS; STRESS; ENDOCRINE; MONKEYS; IMPACT; MODEL; ACTH; AGE;

D O I：

10.1111/jmp.12602

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We conducted a dose-response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.

引用

页码：407 / 410

页数：4

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