Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

被引：494
作者：
Siomi, Haruhiko [1 ]
Siomi, Mikiko C. [1 ]
机构：
[1] Keio Univ, Sch Med, Dept Mol Biol, Shinjuku Ku, Tokyo 1608582, Japan
来源：
MOLECULAR CELL | 2010年 / 38卷 / 03期
关键词：
ALGA CHLAMYDOMONAS-REINHARDTII; EMBRYONIC STEM-CELLS; SMALL RNAS; CAENORHABDITIS-ELEGANS; STRAND SELECTION; MESSENGER-RNAS; CODING REGIONS; EXPRESSION; COMPLEX; DROSOPHILA;
D O I：
10.1016/j.molcel.2010.03.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.
引用
收藏
页码：323 / 332
页数：10
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