Cerebral microbleeds in predialysis patients with chronic kidney disease

被引：58

作者：

Shima, Hideaki ^{[2
]}

Ishimura, Eiji ^{[1
]}

Naganuma, Toshihide ^{[3
]}

Yamazaki, Takeshi ^{[3
]}

Kobayashi, Ikue ^{[2
]}

Shidara, Kaori ^{[2
]}

Mori, Katsuhito ^{[2
]}

Takemoto, Yoshiaki ^{[3
]}

Shoji, Tetsuo ^{[2
]}

Inaba, Masaaki ^{[2
]}

Okamura, Mikio ^{[4
]}

Nakatani, Tatsuya ^{[3
]}

Nishizawa, Yoshiki ^{[2
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Nephrol, Osaka 558, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Endocrinol Metab & Mol Med, Osaka 558, Japan

[3] Osaka City Univ, Grad Sch Med, Dept Urol, Osaka 558, Japan

[4] Ohno Mem Hosp, Osaka, Japan

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 05期

关键词：

arteriosclerosis; chronic kidney disease; microbleeds; T2*-weighted magnetic resonance imaging; GENERAL JAPANESE POPULATION; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; RISK-FACTORS; INTRACEREBRAL HEMORRHAGE; T2-ASTERISK-WEIGHTED MRI; ELDERLY POPULATION; DIABETES-MELLITUS; RENAL-DISEASE; STROKE;

D O I：

10.1093/ndt/gfp694

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Methods. In this cross-sectional study, T2*-weighted MRI of brain was performed with a 1.5-T MRI system in 162 CKD patients (CKD stages 1-5, excluding CKD stage 5(D)) and 24 normal subjects. Results. CMBs were found in 35 CKD patients (25.6%), but not in control subjects. CMBs were more prevalent in male patients, in those with higher blood pressure, advanced age and poor kidney function. There was a significant association between the prevalence of CMBs and the CKD stage, with higher prevalence of CMBs as the CKD stages advanced (P < 0.01). Estimated glomerular filtration rate was a significant factor associated with the prevalence of CMBs, independent of age, gender and hypertension. There was no significant relationship between CMBs and the presence of diabetes mellitus and dyslipidemia. Conclusions. Decreased renal function is a significant risk factor for CMBs, independent of the presence of hypertension. Poor kidney function could be associated with future cerebrovascular events.

引用

页码：1554 / 1559

页数：6

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