Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children

被引：22
作者：
Damnjanovic, Tatjana [2 ]
Milicevic, Radomir
Novkovic, Tanja
Jovicic, Olivera
Bunjevacki, Vera [2 ]
Jekic, Biljana [2 ]
Lukovic, Ljiljana [2 ]
Novakovic, Ivana [2 ]
Redzic, Danka [3 ]
Milasin, Jelena [1 ]
机构：
[1] Univ Belgrade, Inst Human Genet, Sch Dent, Belgrade 11000, Serbia
[2] Inst Human Genet, Sch Med, Belgrade, Serbia
[3] Mother & Child Hlth Inst Serbia, Belgrade, Serbia
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 04期
关键词：
MTHFR polymorphisms; acute lymphoblastic leukemia; risk factor; LYMPHOCYTIC-LEUKEMIA; MTHFR; SUSCEPTIBILITY; POPULATION; C677T;
D O I：
10.1097/MPH.0b013e3181cbd252
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.
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收藏
页码：E148 / E150
页数：3
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