Risk factors for progression of chronic kidney disease

被引:48
作者
Staples, Amy [1 ]
Wong, Craig [1 ]
机构
[1] Univ New Mexico, Dept Pediat, Div Pediat Nephrol, Childrens Hosp, Albuquerque, NM 87131 USA
关键词
anemia; blood pressure; chronic kidney disease; genome-wide association studies; proteinuria; risk factors; STAGE RENAL-DISEASE; GLOMERULAR-FILTRATION-RATE; GENOME-WIDE ASSOCIATION; BLOOD-PRESSURE CONTROL; 9 GENE MYH9; FRAMINGHAM HEART; ATHEROSCLEROSIS RISK; DIABETIC-NEPHROPATHY; AFRICAN-AMERICANS; ANEMIA CORRECTION;
D O I
10.1097/MOP.0b013e328336ebb0
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Purpose of review The present review provides an overview of the identified risk factors for chronic kidney disease (CKD) progression emphasizing the pediatric population. Recent findings Over the past 10 years, there have been significant changes to our understanding and study of preterminal kidney failure. Recent refinements in the measurement of glomerular filtration rate and glomerular filtration rate estimating equations are important tools for identification and association of risk factors for CKD progression in children. In pediatric CKD, lower level of kidney function at presentation, higher levels of proteinuria, and hypertension are known markers for a more rapid decline in glomerular filtration rate. Anemia and other reported risk factors from the pregenomic era require further study and validation. Genome-wide association studies have identified genetic loci that have provided novel genetic risk factors for CKD progression. Summary With cohort studies of children with CKD becoming mature, they have started to yield important refinements to the assessment of CKD progression. Although many of the traditional risk factors for renal progression will certainly be assessed, such cohorts will be important for evaluating novel risk factors identified by genome-wide studies.
引用
收藏
页码:161 / 169
页数:9
相关论文
共 79 条
[1]   Obesity and preterm birth: additive risks in the progression of kidney disease in children [J].
Abitbol, Carolyn L. ;
Chandar, Jayanthi ;
Rodriguez, Maria M. ;
Berho, Mariana ;
Seeherunvong, Wacharee ;
Freundlich, Michael ;
Zilleruelo, Gaston .
PEDIATRIC NEPHROLOGY, 2009, 24 (07) :1363-1370
[2]   Longitudinal Formulas to Estimate GFR in Children with CKD [J].
Abraham, Alison G. ;
Schwartz, George J. ;
Furth, Susan ;
Warady, Bradley A. ;
Munoz, Alvaro .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (11) :1724-1730
[3]   Association of mortality and hospitalization with achievement of adult hemoglobin targets in adolescents maintained on hemodialysis [J].
Amaral, Sandra ;
Hwang, Wenke ;
Fivush, Barbara ;
Neu, Alicia ;
Frankenfield, Diane ;
Furth, Susan .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (10) :2878-2885
[4]  
[Anonymous], 2007, VASC HEALTH RISK MAN, V3, P783
[5]   Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy -: Data from the ItalKid Project [J].
Ardissino, G ;
Testa, S ;
Daccò, V ;
Viganò, S ;
Taioli, E ;
Claris-Appiani, A ;
Procaccio, M ;
Avolio, L ;
Ciofani, A ;
Dello Strologo, L ;
Montini, G .
PEDIATRIC NEPHROLOGY, 2004, 19 (02) :172-177
[6]   Epidemiology of chronic renal failure in children:: Data from the ItalKid Project -: art. no. e382 [J].
Ardissino, G ;
Daccò, V ;
Testa, S ;
Bonaudo, R ;
Claris-Appiani, A ;
Taioli, E ;
Marra, G ;
Edefonti, A ;
Sereni, F .
PEDIATRICS, 2003, 111 (04) :e382-387
[7]  
Arrondel C, 2002, J AM SOC NEPHROL, V13, P65, DOI 10.1681/ASN.V13165
[8]   A genome scan for diabetic nephropathy in African Americans [J].
Bowden, DW ;
Colicigno, CJ ;
Langefeld, CD ;
Sale, MM ;
Williams, A ;
Anderson, PJ ;
Rich, SS ;
Freedman, BI .
KIDNEY INTERNATIONAL, 2004, 66 (04) :1517-1526
[9]   LOW-DOSE SUBCUTANEOUS RECOMBINANT ERYTHROPOIETIN IN CHILDREN WITH CHRONIC-RENAL-FAILURE [J].
BURKE, JR .
PEDIATRIC NEPHROLOGY, 1995, 9 (05) :558-561
[10]  
Chandra M, 1988, Adv Pediatr, V35, P361